摘要
目的:探讨肺泡一氧化氮(Concentration of alveolar nitric oxide,CaNO)与儿童哮喘控制水平的相关性。方法:纳入56例新诊断或未经规范化治疗的哮喘患儿,收集入组前及规范化治疗3个月后的临床资料,根据3个月后随访的哮喘控制测试(ACT)问卷评分,将患儿分为控制组(35例)及未控制组(21例),并选取同期健康体检儿童为对照组(50例),分别收集其一般资料、呼出气一氧化氮(Fractional exhaled nitric oxide,FeNO)和肺泡一氧化氮结果,进行统计分析比较。结果:哮喘患儿FeNO和CaNO水平均高于正常健康儿童,经过规范化治疗3个月后,患儿FeNO、CaNO水平均较治疗前降低,差异有统计学意义(P<0.05)。治疗前未控制组患儿FeNO、CaNO水平较控制组高,两组仅CaNO水平差异有统计学意义(P<0.05);规范化治疗3个月后,控制组患儿FeNO、CaNO水平较对照组高,两组仅CaNO水平差异有统计学意义(P<0.05)。结论:哮喘患儿治疗前后的FeNO、CaNO水平可用于评估患儿的治疗效果,在哮喘规范化治疗过程中,CaNO水平恢复较FeNO水平慢,CaNO可能在预测患儿哮喘控制方面有重要临床价值。
Objective:To explore the correlation between alveolar nitric oxide(CaNO)and the level of asthma control in children.Methods:A total of 56 children with newly diagnosed or without standardized treatment with asthma were concluded.The clinical data before enrollment and 3 months after standardized treatment were collected.According to the Asthma Control Test(ACT)questionnaire scores followed up 3 months later,the patients were divided into controlled group(35 cases)and uncontrolled group(21 cases).And children who underwent physical examination during the same period as control group(50 cases).The general data,FeNO and CaNO were statistically analysed.Results:The levels of FeNO and CaNO in children with asthma were higher than those in normal healthy children,and the levels of FeNO and CaNO were lower than before treatment after 3 months of standardized treatment,and the differences were statistically significant(P<0.05).Before treatment,the FeNO and CaNO levels in the uncontrolled group were higher than those in the controlled group,but only the difference in CaNO levels was statistically significant(P<0.05),and after 3 months after standardized treatment,the FeNO levels in the uncontrolled group were higher than those in the control group,but the difference was not statistically significant(P>0.05).After 3 months of standardized treatment,the level of CaNO in the controlled group was higher than that in the control group,but only the difference in CaNO levels was statistically significant(P<0.05).Conclusion:The levels of FeNO and CaNO before and after treatment can be used to evaluate the treatment effect of the children.The recovery of CaNO levels is slower than that of FeNO.CaNO may have important clinical value in predicting asthma control in children.
作者
刘金辉
郑丹妮
殷汇溪
谢健生
LIU Jin-hui;ZHENG Dan-ni;YIN Hui-xi;XIE Jian-sheng(Department of Paediatrics,The Fifth Affiliated Hospital of Southern Medical University,Guangzhou,Guangdong 510900)
出处
《赣南医学院学报》
2023年第7期696-699,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
