摘要
目的探讨呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)联合外周血嗜酸性粒细胞(eosinophil,Eos)在学龄前儿童支气管哮喘诊疗中的应用。方法选取2019年7月~2021年6月于徐州市儿童医院就诊的91例3~6岁哮喘急性发作期患儿作为哮喘组,同时选取健康体检的41例儿童作为对照组。哮喘组患儿给予规律抗哮喘药物治疗,并依据临床症状控制情况将哮喘患儿分为未控制组、部分控制组与完全控制组。收集治疗前后患儿FeNO及外周血Eos计数的检测结果,Pearson相关性分析用于评价FeNO与外周血Eos的相关性,受试者工作特征(receiver operating characteristic,ROC)曲线用于评价FeNO联合外周血Eos对学龄前儿童哮喘控制水平的预测价值。结果哮喘组患儿FeNO及外周血Eos均显著高于对照组(P均<0.05),且FeNO与外周血Eos水平呈正相关(r=0.474,P<0.05);哮喘经规律治疗后,部分控制组与完全控制组患儿FeNO与外周血Eos水平较哮喘急性发作时均显著下降(P均<0.05),且完全控制组患儿FeNO与外周血Eos水平更低于部分控制组(P<0.05)。FeNO联合外周血Eos预测哮喘控制水平的曲线下面积(areaunderthe curve,AUC)为0.841。结论学龄前儿童支气管哮喘急性发作时FeNO与外周血Eos水平相较于健康儿童明显升高,且两者呈正相关;FeNO联合外周血Eos对学龄前儿童哮喘控制水平的预测具有一定价值。
Objective To explore the application of fractional exhaled nitric oxide(FeNO)combined with peripheral blood eosinophils(Eos)in the diagnosis and treatment of bronchial asthma in preschool children.Methods A total of 91 children aged 3-6 with acute asthma exacerbation admitted to Xuzhou Children's Hospital from July 2019 to June 2021 were selected as asthma objects,and 41healthy children were selected as control group.Children in the asthma group were given regular anti-asthma drug treatment,and were divided into uncontrolled group,partial control group and complete control group according to clinical symptom control.The detection results of FeNO and peripheral blood Eos in these groups were collected before and after treatment.Pearson correlation analysis was used to evaluate the correlation between FeNO and Eos in peripheral blood.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of FeNO combined with peripheral blood Eos in preschool children with asthma control level.Results FeNO and peripheral blood Eos in the asthma group were significantly higher than those in the control group(P<0.05),and there was a positive correlation between FeNO and Eos levels in peripheral blood(r=0.474,P<0.05);After regular treatment in the asthma group,the levels of FeNO and peripheral blood Eos in the partial control group and the complete control group were significantly lower than those in the acute asthma attack(P<0.05),and the levels of FeNO and peripheral blood Eos in the complete control group were lower than those in the partial control group(P<0.05).The area under the curve(AUC)of FeNO combined with Eos in peripheral blood for predicting asthma control level was O.841.Conclusion Compared with healthy children,FeNO and Eos levels in peripheral blood are significantly higher in preschool children with acute attack of bronchial asthma,and there is a positive correlation between them;FeNO combined with Eos in peripheral blood has certain value in the assessment of asthma control level in
作者
龚亮
李文斌
GONG Liang;LI Wenbin(Depurtment of Respiratory Internal Medicine,Xuzhou Children's Hospital,Jiangsu 221006,China)
出处
《医学研究杂志》
2023年第8期181-184,共4页
Journal of Medical Research
