摘要
目的分析郑州市2018—2022年呼吸道感染患儿肺炎支原体(MP)感染的流行病学特征。方法抽取郑州大学第一附属医院2018年3月至2022年6月收治的520例呼吸道感染门诊患儿作为研究对象。采集患儿血液、痰液标本,检测MP IgM抗体阳性率、MP耐药性。分析不同年份、季节、年龄的MP感染变化趋势。结果520例呼吸道感染中,130例发生MP感染,且MP阳性率逐年增多(P<0.05)。130例MP感染患儿中,不同季节性MP感染率比较差异有统计学意义(P<0.05),冬季感染率最高,其次是春季。随着年龄增长,郑州地区儿童MP感染率逐渐增长(P<0.05),但5~6岁儿童MP感染率最高,其次为≥7岁儿童。MP对红霉素、乙酰螺旋霉素耐药性相对较高,耐药率分别为17.73%、13.79%。130例MP感染患儿中有55例发生23S rRNA基因突变,主要突变位点为A2063G。结论郑州地区2018—2022年MP感染儿童逐年增多,冬、春季为高发季节,5~6岁及≥7岁儿童为易感群体,且普遍耐药性较低,可能与A2063G位点突变有关,应对易感群体实施主动预防策略。
Objective To analyze the epidemiological characteristics of Mycoplasma pneumoniae(MP)in children with respiratory tract infection in Zhengzhou from 2018 to 2022.Methods A total of 520 children with respiratory infection admitted to the First Affiliated Hospital of Zhengzhou University from March 2018 to June 2022 were selected as research objects.Blood samples and sputum samples were collected from selected children to detect the positive rate of MP immunoglobulin M antibody and drug resistance of MP.The change trends of MP infection in different years,different seasons and different ages were analyzed.Results Among the 520 children with respiratory infection,130 children developed MP infection,and the positive rate of MP increased year by year(P<0.05).The MP infection rate of the 130 children was significantly different in different seasons(P<0.05),and the infection rate in winter was the highest,followed by that in spring.The MP infection rate of children in Zhengzhou increased with age(P<0.05).However,the infection rate of children aged 5-6 years was the highest,followed by that of children aged≥7 years.MP was highly resistant to erythromycin and acetylspiramycin,with resistance rates of 17.73%and 13.79%,respectively.Among the 130 children with MP infection,there were 55 children with 23S rRNA gene mutation,and the main mutation site was A2063G.Conclusions The population of MP-infected children is increasing year by year in Zhengzhou from 2018 to 2022.Winter and spring are high-incidence seasons.Children aged 5-6 years are susceptible groups.and The drug resistance is generally low,which may be related to A2063G mutation.Active prevention strategies should be implemented for susceptible groups.
作者
宋瑞
秦楠
司瑞品
Song Rui;Qin Nan;Si Ruipin(Department of Pediatrics Clinic,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用医刊》
2023年第11期53-56,共4页
Chinese Journal of Practical Medicine
关键词
肺炎支原体
呼吸道感染
儿童
流行病学
Mycoplasma pneumoniae
Respiratory infection
Child
Epidemiology
