摘要
目的观察TACE治疗原发性肝癌后并发肝脓肿的影响因素。方法采用倾向性评分匹配法回顾性收集99例接受TACE治疗的原发性肝癌患者,其中26例TACE后并发、73例未并发肝脓肿;根据治疗方式将其分为传统TACE(cTACE)组(n=48)和药物栓塞微球TACE(DTACE)组(n=51)。比较并发肝脓肿与未并发肝脓肿患者临床资料的差异,以logistic回归分析筛选TACE治疗原发性肝癌后并发肝脓肿的影响因素。结果TACE治疗原发性肝癌后并发与未并发肝脓肿患者之间,肿瘤供血血管数目、碘油量及栓塞剂种类差异均有统计学意义(P均<0.05)。cTACE组内并发与未并发肝脓肿患者血糖及栓塞剂种类差异有统计学意义(P均<0.05);DTACE组内并发与未并发肝脓肿患者碘油量差异有统计学意义(P<0.05)。TACE治疗原发性肝癌后并发肝脓肿的保护因素为患者年龄<55岁、无靶向药物联合免疫检查点抑制剂治疗史(靶免史)、仅栓塞1支肿瘤供血动脉、碘油量少及仅使用1种栓塞剂,TACE次数≥3则为危险因素(P均<0.05)。结论患者年龄、靶免史、TACE次数、肿瘤供血血管数目、碘油量及栓塞剂种类均为TACE治疗原发性肝癌后并发肝脓肿的影响因素。
Objective To explore the influence factors of development of liver abscess after TACE for treating primary liver cancer.Methods A total of 99 patients with primary liver cancer who underwent TACE selected with propensity score matching were retrospectively enrolled,including 26 developed liver abscess after TACE and 73 patients did not.The patients were divided into conventional TACE(cTACE)group(n=48)or drug-eluting bead TACE(DTACE)group(n=51)according to the method of TACE.Clinical data were compared between patients with and without liver abscess,and logistic regression analysis was performed to screen the influence factors of liver abscess after TACE.Results Significant differences of the number of tumor blood supply vessels,the amount of iodine oil and kinds of embolic agents were found between patients with and without liver abscess after TACE(all P<0.05).In cTACE group,there were significant differences of blood glucose levels and kinds of embolic agents between patients with and without liver abscess(all P<0.05),while in DTACE group,significant difference of the amount of iodine oil was detected between patients with and without liver abscess(P<0.05).Patient's age<55 years old,no history of targeted agents plus immune checkpoint inhibitors,embolization of only 1 tumor blood supply vessel,lower amount of iodine oil and using only 1 kind of embolic agent were the protective factors of liver abscess after TACE for treating primary liver cancer,whereas the times of TACE≥3 was the risk factor(all P<0.05).Conclusion Patients'age,history of targeted agents plus immune checkpoint inhibitors,numbers of tumor blood supply vessels,times of TACE,amount of iodine oil and kinds of embolic agents were influence factors of development of liver abscess after TACE for treating primary liver cancer.
作者
徐衡
袁牧
XU Heng;YUAN Mu(Department of Interventional Medicine,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China)
出处
《中国介入影像与治疗学》
北大核心
2023年第9期522-526,共5页
Chinese Journal of Interventional Imaging and Therapy
关键词
癌
肝细胞
肝脓肿
化学栓塞
治疗性
carcinoma,hepatocellular
liver abscess
chemoembolization,therapeutic
