摘要
目的:探讨载药微球肝动脉化疗栓塞(DEB-TACE)与基于碘化油经动脉化疗栓塞(cTACE)治疗消化系统肿瘤肝转移的临床疗效。方法:选取2017年3月—2021年10月无法手术的消化系统肝转移瘤患者42例,根据治疗方案分为微球组(16例)和碘化油组(26例)。比较两组术后的客观缓解率(ORR)、疾病控制率(DCR)、不良反应情况及肝功能变化。结果:微球组的ORR及DCR分别为56.3%和87.5%,高于碘化油组的19.2%和57.7%;术后1周,碘化油组肝功能损伤程度更高,差异有统计学意义(P<0.05)。结论:DEB-TACE治疗消化系统肝转移瘤的疗效更佳,肝功能损伤程度及不良反应发生率均低于cTACE,更加安全有效。
Objective: To explore the clinical efficacy of hepatic artery chemoembolization with drug-loaded microspheres(DEB-TACE) and transcatheter arterial chemoembolization with iodized oil(cTACE) in the treatment of hepatic metastasis of digestive system tumors.Methods: A total of 42 patients with inoperable digestive liver metastases from March 2017 to October 2021 were divided into microsphere group(16 cases) and iodized oil group(26 cases) according to the treatment plan, and the objective response rate(ORR),disease control rate(DCR),adverse reactions and changes in liver function after surgery in the two groups were compared.Results: The ORR and DCR of microsphere group were 56.3% and 87.5% respectively, while that of iodized oil group was 19.2% and 57.7%.One week after operation, the degree of liver function damage in lipiodol group was higher, and the difference was statistically significant(P<0.05).Conclusion: Drug-loaded microspheres have a better therapeutic effect on liver metastases of digestive system, and the degree of liver injury and the incidence of adverse reactions are lower than those of iodized oil embolization, which is safe and effective.
作者
汪恒望
熊崇
WANG Hengwang;XIONG Chong(Chongyang County Hospital of Traditional Chinese Medicine,Chongyang 437500,China)
出处
《临床医药实践》
2023年第1期37-39,共3页
Proceeding of Clinical Medicine
