摘要
综述中药单体靶向磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路防治糖尿病肾病(DN)的研究进展。研究表明,PI3K/Akt/mTOR信号通路可以抑制炎症反应、氧化应激、细胞凋亡和自噬,在DN发生发展中起着重要作用;中药单体(黄芩苷、石斛碱、姜黄素、三七皂苷R1、桔梗皂苷D、蛇床子素)可通过靶向调控该信号通路有效防治DN。
This article reviewed the research progress in monomers of traditional Chinese herbal medicine targeting PI3K/Akt/mTOR signaling pathway to prevent and treat diabetic nephropathy(DN).Studies have shown that PI3K/Akt/mTOR signaling pathway can inhibit inflammatory reaction,oxidative stress,apoptosis and autophagy,and plays an important role in the development and progression of DN.Monomers of traditional Chinese herbal medicine(baicalin,dendrobine,curcumin,notoginsenoside R1,platycodin D and osthole)can effectively prevent and treat DN by regulating PI3K/Akt/mTOR signaling pathway.
作者
王婉婷
许颖
邵命海
WANG Wanting;XU Ying;SHAO Minghai(Nephrology Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;TCM Institute of Kidney Disease,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai 201203,China;Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China)
出处
《上海中医药杂志》
CSCD
2023年第10期83-88,共6页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81973807)
上海市浦东新区卫生系统重点学科群建设项目(PWZxq2017-07)。
关键词
糖尿病肾病
中药
作用机制
研究进展
diabetic nephropathy
traditional Chinese herbal medicine
mechanism of action
research progress
