摘要
目的探讨维持性血液透析患者平均血小板体积(MPV)和β_(2)-微球蛋白与心脏瓣膜钙化(CVC)的关系,为CVC的临床预测和诊断提供依据。方法选择行规律血液透析患者70例,根据有无CVC分为2组,无CVC组36例,有CVC组34例,比较2组患者性别、年龄、透析龄、血磷、血钙、甲状旁腺激素、25-羟维生素D3、白蛋白、前白蛋白、铁、不饱和铁、转铁蛋白、铁蛋白、总铁结合力、碱性磷酸酶、血脂、β_(2)-微球蛋白、MPV、中性粒细胞与淋巴细胞比值(NLR)的差异,并应用Logistic回归分析CVC发生的危险因素。结果与无CVC组比较,CVC组的年龄、透析龄、MPV、β_(2)-微球蛋白、NLR均明显升高,差异均有统计学意义(P均<0.05)。Logistic回归分析结果显示,年龄(OR=1.101,P=0.018)、MPV(OR=2.894,P=0.003)、β_(2)-微球蛋白(OR=1.064,P=0.038)是维持性血液透析患者发生CVC的独立危险因素。结论MPV及β_(2)-微球蛋白与维持性血液透析患者CVC发生、发展密切相关,是影响CVC的独立危险因素。
Objective To investigate the relationship between mean platelet volume(MPV)andβ_(2)-microglobulin and cardiac valve calcifi cation(CVC)in maintenance hemodialysis patients,aiming to provide a basis for clinical prediction and diagnosis of CVC.Meth ods Seventy patients on regular hemodialysis were selected and divided into the non-CVC(n=36)and CVC groups(n=34)according to the presence or absence of CVC.Gender,age,dialysis age,blood phosphorus,blood calcium,parathyroid hormone,25 hydroxy-vitamin D3,albumin,prealbumin,iron,unsaturated iron,transferrin,ferritin total iron binding capacity,alkaline phosphatase,lipids,β_(2)-microglobulin,MPV and neutrophil-to-lymphocyte ratio(NLR)were statistically compared between two groups.The risk factors for the incidence of CVC were assessed by Logistic regression analysis.Results Compared with the non-CVC group,age,dialysis age,MPV,β_(2)-microglobulin and NLR were signifi cantly higher in the CVC group,and all diff erences were statistically signifi cant(all P<0.05).Logistic regression analysis showed that age(OR=1.101,P=0.018),MPV(OR=2.894,P=0.003),andβ_(2)-microglobulin(OR=1.064,P=0.038)were the independent risk factors for the incidence of CVC in maintenance hemodialysis patients.Conclusion MPV andβ_(2)-microglobu lin are closely associated with the occurrence and development of CVC in maintenance hemodialysis patients,which are independent risk factors aff ecting CVC.
作者
姚转娥
王鹏波
付秦娟
王薇
宋琼
李欢
刘爱
张鹏
Yao Zhuan’e;Wang Pengbo;Fu Qinjuan;Wang Wei;Song Qiong;Li Huan;Liu Ai;Zhang Peng(Department of Nephrology,the Second People’s Hospital of Shanxi Province,Xi’an 710005,China)
出处
《新医学》
CAS
2023年第9期634-638,共5页
Journal of New Medicine
基金
陕西省卫生健康科研基金(2022E013)。
