摘要
目的探讨生脉强心颗粒治疗慢性心力衰竭的临床效果及安全性。方法选取2021年3月—2022年9月期间黑龙江中医药大学附属第二医院收治的慢性心力衰竭患者94例,按随机数字表法分为对照组和研究组,每组各47例。两组患者入院后均给予常规干预,研究组在上述基础上采取生脉强心颗粒,共治疗30 d。观察比较两组患者治疗效果、不良反应发生情况及治疗前后中医证候积分、心功能[舒张早期血流峰值速度(Early peak mitral valve diastolic flow rate,E)/舒张晚期血流峰值速度(Peak mitral orifice blood flow velocity in late diastolic period,A)、左室短轴缩短率(Fractional shortening,FS)、左心室射血分数(Left ventricular ejection fraction,LVEF)、左心室舒张末内径(Left ventricular end-diastolic diameter,LVEDD)、舒张末室间隔厚度(Interventricular Septal Thickness at Diastole,IVST)、左室后壁厚度(Left ventricular posterior wall thickness,LVPWT)]、血脑钠肽(Blood brain natriuretic peptide,BNP)及C反应蛋白(C-reactive protein,CRP)水平、运动耐量(6 Minute Walk Test,6MWT)及生活质量(Minnesota Living with Heart Failure Questionnaire,MLHFQ)。结果(1)治疗后两组患者主症、次症分值较治疗前降低,差异有统计学意义(P<0.05);且研究组低于对照组,差异有统计学意义(P<0.05)。(2)治疗后研究组临床总有效率93.62%(44/47)明显高于对照组78.72%(37/47),差异有统计学意义(P<0.05)。(3)治疗后两组患者E/A、FS、LVEF较治疗前升高,LVEDD、IVST、LVPWT较治疗前降低,差异有统计学意义(P<0.05),且研究组E/A、FS、LVEF高于对照组,LVEDD、IVST、LVPWT低于对照组,差异有统计学意义(P<0.05)。(4)治疗后两组患者血BNP及CRP水平较治疗前降低,差异有统计学意义(P<0.05);且研究组低于对照组,差异有统计学意义(P<0.05)。(5)治疗后两组患者6MWT较治疗前升高,MLHFQ较治疗前降低,差异有统计学意义(P<0.05);且研究组6MWT高于对照组,M
Objective To investigate the clinical effect and safety of Shengmai Qiangxin Granules in the treatment of chronic heart failure.Methods A total of 94 patients with chronic heart failure admitted to the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from March 2021 to September 2022 were selected and divided into a study group and control group according to the random number table,with 47 patients in each group.Both groups were given routine intervention after admission.On the basis of the above,the study group was treated with Shengmai Qiangxin Granules for 30 days.The treatment effect,occurrence of adverse reactions,TCM syndrome scores before and after treatment,cardiac function(early peak mitral valve diastolic flow rate(E),peak mitral orifice blood flow velocity in late diastolic period(A),fractional shortening(FS),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),interventricular septal thickness at diastole(IVST),and left ventricular posterior wall thickness(LVPWT),blood brain natriuretic peptide(BNP)and C-reactive protein(CRP)levels,exercise tolerance(6 minute) walk test(6MWT),and quality of life(minnesota living with heart failure questionnaire(MLHFQ)were compared.Results(1)After treatment,the scores of the main disease and secondary disease in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05);the study group was lower than the control group(P<0.05).(2)The total effective rate of the study group 93.62%(44/47)was significantly higher than that of the control group 78.72%(37/47)(P<0.05).(3)After treatment,E/A,FS,and LVEF in the two groups were higher than those before treatment;LVEDD,IVST,and LVPWT were lower than those before treatment(P<0.05),and E/A,FS,and LVEF in the study group were higher than those in the control group,while LVEDD,IVST,and LVPWT in the study group were lower than those in the control group(P<0.05).(4)After treatment,the levels of blood BNP and CRP in the two gr
作者
徐倩
万冬梅
邓立梅
高媛
田淇元
XU Qian;WAN Dong-mei;DENG Li-mei;GAO Yuan;TIAN Qi-yuan(Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150040;Department of Cardiology,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150001;Department of Cardiology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150040)
出处
《世界中西医结合杂志》
2023年第7期1375-1380,共6页
World Journal of Integrated Traditional and Western Medicine
基金
黑龙江省中医药科研项目(ZHY2022-166)。
关键词
生脉强心颗粒
慢性心力衰竭
心功能
运动耐量
生活质量
Shengmai Qiangxin Granules
Chronic Heart Failure
Cardiac Function
Exercise Tolerance
Quality of Life
