摘要
目的 研究硝苯地平联合低分子肝素钙治疗重度子痫前期(sverepreeclampsia,SPE)的效果及对凝血功能的影响。方法 使用随机数字表法将2019年2月—2021年2月于惠州市第一妇幼保健院产科剖宫产分娩的98例SPE患者分为对照组和联合组,各49例。对照组使用硝苯地平治疗,联合组使用硝苯地平联合低分子肝素钙治疗。对比2组的治疗效果、血压、凝血功能、不良妊娠结局。结果 联合组的治疗总有效率(97.96%)高于对照组(85.71%)(P<0.05);治疗前2组的收缩压(systolic blood pressure,SBP)、舒张压(diastole blood pressure,DBP)比较差异无统计学意义(P>0.05),治疗后2组的SBP、DBP均低于治疗前,且联合组低于对照组(P<0.05);治疗前2组的FIB、PT、APTT、D-D比较差异无统计学意义(P>0.05),治疗后联合组的纤维蛋白原(FIB)、D-二聚体(D-D)低于对照组,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)长于对照组(P<0.05);联合组的不良妊娠结局发生率(4.08%)低于对照组(18.36%)(P<0.05)。结论 硝苯地平联合低分子肝素钙治疗SPE的效果显著,能够降低血压,改善凝血功能,减少不良妊娠结局的发生,值得应用。
Objective To study the effect of nifedipine(Nif)combined with lowmolecular weight heparin calcium in the treatment of severe preeclampsia(severe preeclampsia,SPE)and its effect on coagulation function.Methods Using the random number table method,98 patients with SPE who were delivered by cesarean section in the obstetrics department of Huizhou First Maternal and Child Health Hospital from February 2019 to February 2021 were divided into the control group and the combined group,with 49 cases in each group.The control group was treated with NIF,and the combined group was treated with NIF combined with lowmolecular weight heparin calcium.The therapeutic effect,blood pressure,coagulation function and adverse pregnancy outcome were compared between the two groups.Results The effective rate of the combined group(97.96%)was higher than that of the control group(85.71%)(P<0.05).There was no statistical difference in systolic blood pressure(SBP)and diastole pressure(DBP)between the two groups before treatment(P>0.05)After treatment,the SBP and DBP of the two groups were lower than those before treatment,and the combination group was lower than the control group(P<0.05).There was no difference in FIB,PT,APTT and D-D between the two groups before treatment(P>0.05).Statistical significance,fibrinogen(FIB)and D-dimer(D-D)in the combined group after treatment were lower than those in the control group,prothrombin time(PT),activated partial thromboplastin time(APTT)was longer than that in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the combined group(4.08%)was lower than that in the control group(18.36%)(P<0.05).Conclusion NIF combined with low molecular weight heparin calcium is effective in the treatment of SPE.It can reduce blood pressure,improve coagulation function and reduce adverse pregnancy outcomes.It is worthy of application.
作者
董学培
刘硕锟
罗崇文
Dong Xuepei;Liu Shuokun;Luo Chongwen(The Huizhou First Maternal and Child Health Hospital,Huizhou,Guangdong 516300)
出处
《基层医学论坛》
2023年第23期11-13,16,共4页
The Medical Forum
关键词
重度子痫前期
硝苯地平
低分子肝素钙
凝血功能
Severe preeclampsia
Nifedipine
Lowmolecular weight heparin calcium
Coagulation function
