摘要
目的探讨股骨头坏死患者血瘀量化评分与血细胞参数之间的关系。方法选择2019年11月至2021年11月在河南省骨科医院中医骨病科确诊为股骨头坏死(痰瘀阻络证)患者68例,河南中医药大学骨伤学院参照李东涛等人对骨质疏松症血瘀证的量化评价方法,基于中医异病同治原理,采用相同方法对股骨头坏死血瘀证进行量化评价,通过客观分值判定血瘀轻重程度。记录每位患者血细胞参数(MCV、RDW-cv、MPV、PDW)以及年龄,进一步对股骨头坏死(痰瘀阻络证)患者血瘀量化评分和各血细胞参数、年龄分别进行Spearman相关性分析。结果MPV、MCV水平与股骨头坏死(痰瘀阻络证)血瘀量化评分呈现中度正相关(r_(s)=0.423,P=0.007;r_(s)=0.517,P=0.001),而PDW、RDW-CV水平与股骨头坏死(痰瘀阻络证)血瘀量化评分无等级相关关系(r_(s)=-0.050,P=0.687;r_(s)=-0.029,P=0.813)。MCV水平与患者年龄呈低度正相关(r_(s)=0.324,P=0.007),PDW水平与患者年龄呈中度负相关(r_(s)=-0.403,P=0.001),RDW-cv、MPV水平与年龄无等级相关关系(r_(s)=0.196,P=0.110;r_(s)=0.164,P=0.181)。结论本研究从微观水平上证实了股骨头坏死血瘀程度与血细胞参数等指标显著相关性,血瘀是股骨头坏死发病的重要病理基础,也为临床对股骨头坏死的早诊早治及机制研究提供一定帮助。
Objective To investigate the relationship between blood stasis quantitative score and blood cell parameters in patients with femoral head necrosis.Methods Totally 68 patients with femoral head necrosis(phlegm and blood stasis blocking collaterals syndrome)diagnosed in the Department of traditional Chinese medicine orthopedics of Henan orthopaedic hospital from November 2019 to November 2021 were selected.Referring to the quantitative evaluation method of blood stasis syndrome of osteoporosis by Li Dongtao and others,based on the principle of simultaneous treatment of different diseases in traditional Chinese medicine,we used the same method to quantitatively evaluate the blood stasis syndrome of femoral head necrosis,and determined the degree of blood stasis through objective scores.The blood cell parameters(MCV,RDW CV,MPV,PDW)and age of each patient were recorded.The quantitative score of blood stasis,blood cell parameters and age of patients with femoral head necrosis(phlegm and blood stasis blocking collaterals syndrome)were further analyzed by Spearman correlation.Results The levels of MPV and MCV showed moderate positive correlation with the quantitative score of blood stasis in femoral head necrosis(phlegm and blood stasis blocking collaterals syndrome)(r_(s)=0.423,P=0.007;r_(s)=0.517,P=0.001),while the levels of PDW and rdw-cv had no grade correlation with the quantitative score of blood stasis in femoral head necrosis(phlegm and blood stasis blocking collaterals syndrome)(r_(s)=-0.050,P=0.687;r_(s)=-0.029,P=0.813).MCV level was positively correlated with patients'age(r_(s)=0.324,P=0.007),PDW level was negatively correlated with patients'age(r_(s)=-0.403,P=0.001),RDW CV and MPV level had no grade correlation with age(r_(s)=0.196,P=0.110;r_(s)=0.164,P=0.181).Conclusion We confirmed that the degree of blood stasis in femoral head necrosis was significantly correlated with blood cell parameters and other indicators.Blood stasis is an important pathological basis of femoral head necrosis,It also provides some
作者
徐良
任之强
李龙飞
阎晓霞
王震
赵志强
韩崇涛
朱紫燕
XU Liang;REN Zhi-qiang;LI Long-fei;YAN Xiao-xia;WANG Zhen;ZHAO Zhi-qiang;HAN Chong-tao;ZHU Zi-yan(College of Orthopedics and Traumatology,Henan University of Traditional Chinese Medicine,Zhengzhou 450002,China;Henan Orthopedic Hospital,Zhengzhou 450000,China;The Third Affiliated Hospital of Henan University of traditional Chinese Medicine,Zhengzhou 450008,China)
出处
《医药论坛杂志》
2023年第14期6-9,共4页
Journal of Medical Forum
基金
河南省中医药科学研究专项课题(2018ZY2016)
河南省中医拔尖人才项目科研专项(2019ZYBJ21)。
关键词
股骨头坏死
血瘀量化评分
血细胞参数
相关性分析
Necrosis of femoral head
Quantitative score of blood stasis
Blood cell parameters
Correlation analysis
