摘要
目的:探讨中老年体检人群甘油三酯-葡萄糖-体质(TyG-BMI)指数对动脉硬化的预测价值。方法:纳入中老年体检人群542例,根据臂踝动脉脉搏传导速度(baPWV)将其分为正常组(n=204)和动脉硬化组(n=338)。记录2组体检人群的一般资料、血压、血糖及血脂等指标,并计算TyG指数及TyG-BMI指数。采用二元Logistic回归分析和受试者工作特征曲线(ROC曲线)预测TyG指数及TyG-BMI指数在中老年动脉硬化人群中的诊断价值。结果:中老年人群动脉硬化的发生率为62.36%;动脉硬化组人群中的年龄、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、高血压史比例及糖尿病史比例均高于正常组(P<0.05);动脉硬化组人群血清空腹血糖(FBG)、甘油三酯(TG)、TyG指数、TyG-BMI指数、TG/高密度脂蛋白胆固醇(HDL-C)均高于正常组(P<0.05);而动脉硬化组人群血清HDL-C低于正常组(P<0.05);动脉硬化组TyG指数及TyG-BMI指数高于正常组人群(P<0.05);Spearman相关性分析结果显示:baPWV与年龄、BMI、SBP、DBP、FBG、TG、TyG指数、TyG-BMI指数、TG/HDL-C均呈显著正相关(P<0.05),baPWV与HDL-C呈负相关(P<0.05);二元Logistic回归分析结果显示,年龄、SBP、HDL-C、TyG指数、TyG-BMI指数是动脉硬化发生的独立影响因素(P<0.05);ROC曲线分析结果得出TyG指数及TyG-BMI指数对外周动脉硬化的诊断的曲线下面积分别为0.706(95%CI:0.599~0.820,P<0.001)、0.709(95%CI:0.592~0.820,P<0.001),具有一定的预测价值;其中,TyG指数ROC曲线对应的最佳截断值为2.855;TyG-BMI指数在ROC曲线对应的最佳截断值为75.86。结论:TyG指数及TyG-BMI指数在预测中老年患者发生动脉硬化风险上具有一定的应用价值。
Objective:To investigate the predictive value of triglyceride glucose-body mass index(TyG-BMI)for atherosclerosis in middle-aged and elderly people undergoing a physical examination.Methods:A total of 542 middle-aged and elderly people who underwent physical examination.According to brachial-ankle artery pulse velocity(baPWV),they were divided into the normal group(n=204)and the arteriosclerosis group(n=338).The general information,blood pressure,blood glucose,blood lipid,and other indexes of the two groups were recorded,and the TyG index and TyG-BMI index were calculated.Binary Logistic regression analysis and receiver operating characteristics curve(ROC curve)were used to predict the diagnostic value of the TyG index and TyG-BMI index in the middle-aged and elderly arteriosclerosis population.Results:The incidence of arteriosclerosis in the middle-aged and elderly population was 62.36%.The proportion of age,BMI,SBP,DBP,hypertension history,and diabetes history in the atherosclerosis group were higher than those in the normal group(P<0.05).Serum FBG,TG,TyG index,Tyg-BMI index,and TG/HDL-C in the atherosclerosis group were higher than those in the normal group(P<0.05).Serum HDL-C in the arteriosclerosis group was lower than that in the normal group(P<0.05).The TyG index and TyG-BMI index of the arteriosclerosis group were higher than those of the normal group(P<0.05).Spearman correlation analysis showed that baPWV was significantly positively correlated with age,BMI,SBP,DBP,FBG,TG,TyG index,Tyg-BMI index,and TG/HDL-C(P<0.05);baPWV was negatively correlated with HDL-C(P<0.05).Binary Logistic regression analysis showed that age,SBP,HDL-C,TyG index,and Tyg-BMI index were independent factors influencing the occurrence of atherosclerosis(P<0.05).ROC curve analysis results showed that the areas under the curve of TyG index and Tyg-BMI index for the diagnosis of peripheral arteriosclerosis were 0.706(95%CI:0.599~0.820,P<0.001)and 0.709(95%CI:0.592~0.820,P<0.001),with predictive value and accuracy.Among them,the optimal
作者
谢郁芳
陶梦君
刘雅思
芮瑶瑶
张先翠
XIE Yufang;TAO Mengjun;LIU Yasi;RUI Yaoyao;ZHANG Xiancui(Postgraduate School,Wannan Medical College)
出处
《长治医学院学报》
2023年第4期256-260,共5页
Journal of Changzhi Medical College
基金
2022年度安徽省新时代育人质量工程项目(2022zyxwjxalk164)。
