摘要
目的探讨血清镁、同型半胱氨酸水平与痛性糖尿病周围神经病变(PDN)的关系。方法选择2019年6月至2021年6月在镇江市第一人民医院新区分院收治的糖尿病周围神经病变患者78例,将其分为PDN组36例和非PDN组42例,另收集32名非糖尿病体检者作对照组。收集3组对象的一般资料,评估多伦多临床评分系统(TCSS)和视觉模拟量表(VAS),检测血清镁、同型半胱氨酸、IL-6和超氧化物歧化酶(SOD)水平。采用Pearson相关分析血清镁、同型半胱氨酸水平与TCSS评分、VAS评分、血清IL-6和SOD水平的相关性。采用多因素logistic回归评估PDN的影响因素,并绘制相应的ROC曲线。结果PDN组、非PDN组的血清镁、SOD水平低于对照组,血清同型半胱氨酸、IL-6水平高于对照组,PDN组的血清镁、SOD水平低于非PDN组,血清同型半胱氨酸、IL-6水平高于非PDN组,差异均有统计学意义(均P<0.01)。PDN组患者血清镁水平与TCSS评分、VAS评分均呈负相关(r=-0.572、-0.633,均P<0.01),血清同型半胱氨酸水平与TCSS评分、VAS评分均呈正相关(r=0.562、0.584,均P<0.01)。logistic回归分析显示血清镁为PDN的保护因素(P<0.01),血清同型半胱氨酸水平为PDN的危险因素(P<0.01)。血清镁的AUC为0.793,血清同型半胱氨酸的AUC为0.688,两者联合的AUC为0.852。PDN组患者血清镁水平与血清IL-6水平呈负相关(r=-0.657,P<0.01),与血清SOD水平均呈正相关(r=0.614,P<0.01),血清同型半胱氨酸水平与血清IL-6水平呈正相关(r=0.529,P<0.01),与血清SOD水平呈负相关(r=-0.631,P<0.01)。结论PDN患者血清镁水平降低、同型半胱氨酸水平升高,参与PDN后的炎症反应和氧化应激,可用于辅助PDN患者临床病情评估和鉴别。
Objective To explore the relationship between serum magnesium and homocysteine levels and painful diabetic peripheral neuropathy(PDN).Methods Seventy-eight patients with diabetic peripheral neuropathy admitted to the Zhenjiang First People's Hospital Branch from June 2019 to June 2021 were selected,and they were divided into 36 cases of the PDN group and 42 cases of the non-PDN group(UPDN group);another 32 nondiabetic cases who received physical examination were also collected as the control group.General information of the subjects in the three groups was collected;the Toronto clinical scoring system(TCSS)and visual analogue scale(VAS)were assessed;and serum magnesium,homocysteine,IL-6,and superoxide dismutase(SOD)levels were measured.Pearson's correlation was used to analyze the correlation of serum magnesium and homocysteine levels with TCSS score,VAS score,serum IL-6 and SOD levels.Logistic regression was used to assess the influencing factors of PDN,and the corresponding ROC curves were plotted.Results The serum magnesium and SOD levels in the PDN and UPDN groups were lower than those in the control group,while the serum homocysteine and IL-6 levels were higher than those in the control group;the serum magnesium and SOD levels in the PDN group were lower than those in the UPDN group,while the serum homocysteine and IL-6 levels were higher than those in the UPDN group,all with statistically significant differences(all P<0.01).The serum magnesium levels of patients in the PDN group were negatively correlated with the TCSS score and VAS score(r=-0.572,-0.633,both P<0.01),while the serum homocysteine levels were positively correlated with the TCSS score and VAS score(r=0.562,0.584,both P<0.01).Logistic regression analysis showed that serum magnesium was a protective factor for PDN(P<0.01)and serum homocysteine was a risk factor for PDN(P<0.01).The AUC of serum magnesium and homocysteine was 0.793 and 0.688,respectively,while the AUC of the combination of the two was 0.852.In the PDN group,the serum magnesium lev
作者
葛建英
朱圆圆
GE Jianying;ZHU Yuanyuan(Department of Neurology,Zhenjiang First People's Hospital Branch,Zhenjiang 212132,China;不详)
出处
《浙江医学》
CAS
2023年第16期1729-1732,共4页
Zhejiang Medical Journal
