摘要
目的探讨孕19~23周^(+6)正常胎儿羊水γ-谷氨酰转移酶(γ-glutamyl transferase,GGT)水平及其随孕周的变化。方法回顾性收集2021年1月至2022年9月于山东大学齐鲁医院行羊膜腔穿刺产前诊断但遗传学诊断结果正常的383例(孕19~19+6、20~20+6、21~21+6、22~22+6、23~23周^(+6)分别为102、103、82、68和28例)单胎妊娠孕妇的羊水上清液,测定GGT水平。计算各孕周羊水GGT值的x¯±s、min~max、M、P_(1)、P_(2.5)、P_(5)、P_(95)、P_(97.5)和P_(99)。GGT为非正态分布数据,转换为自然对数(lnGGT),采用最小二乘线性回归分析lnGGT与孕周的线性关系。结果孕19~19+6、20~20+6、21~21+6、22~22+6、23~23周^(+6)羊水GGT水平的x¯±s分别为(385.8±235.7)、(331.8±219.4)、(253.7±197.9)、(226.7±166.4)和(155.3±96.8)U/L,每周下降14.0%、23.5%、10.6%和31.5%;M分别为311.0、288.0、199.0、160.5及105.5 U/L,每周下降7.4%、30.9%、19.3%及34.3%;P_(1)~P_(99)分别为67.1~1404.5、63.2~1189.1、36.0~849.8、44.0~787.3及32.0~375.6 U/L。lnGGT与孕周呈负相关(R^(2)=0.148,P<0.001)。结论孕19~23周^(+6)正常胎儿羊水GGT水平随孕周增加而降低,未来建立正常胎儿羊水GGT正常参考值范围时需要考虑孕周的影响。
Objective To detect the levels ofγ-glutamyl transferase(GGT)in the amniotic fluid of normal pregnancies at 19-23^(+6)gestational weeks and to analyze the changes in GGT level with gestational age.Methods This study retrospectively collected the amniotic fluid supernatant from 383 singleton pregnant women(102,103,82,68 and 28 cases at 19-19+6,20-20+6,21-21+6,22-22+6,23-23^(+6)weeks of gestation,respectively)who underwent amniocentesis for prenatal diagnosis but had normal genetic diagnosis results in Cheeloo Hospital of Shandong University from January 2021 to September 2022.The levels of GGT in the amniotic fluid supernatant were tested and the statistical parameters including x¯±s,min-max,median(M),P_(1),P_(2.5),P_(5),P_(95),P_(97.5)and P_(99)values of GGT levels at each gestational week were calculated.GGT were non-normal data and converted into natural logarithms(lnGGT),and a least square linear regression equation was established to analyze the relationship between lnGGT and gestational week.Results At 19-19+6,20-20+6,21-21+6,22-22+6,and 23-23^(+6)gestational weeks,the x¯±s of amniotic fluid GGT were(385.8±235.7),(331.8±219.4),(253.7±197.9),(226.7±166.4),and(155.3±96.8)U/L,and the weekly declines were 14.0%,23.5%,10.6%,and 31.5%,respectively;the M values were 311.0,288.0,199.0,160.5,and 105.5 U/L,and the weekly declines were 7.4%,30.9%,19.3%,and 34.3%,respectively;the P_(1)-P_(99)were 67.1-1404.5,63.2-1189.1,36.0-849.8,44.0-787.3,and 32.0-375.6 U/L,respectively.lnGGT was negatively correlated with gestational age(R^(2)=0.148,P<0.001).Conclusions In normal pregnancies at 19-23^(+6)gestational weeks,GGT levels in amniotic fluid decrease with gestational age.Therefore,gestational age should be considered when establishing the reference value for amniotic fluid GGT in normal pregnancies.
作者
徐亚瑄
陶国伟
孙平
宋珍
孙秀彬
张丽华
丛翔
Yaxuan Xu;Guowei Tao;Ping Sun;Zhen Song;Xiubin Sun;Lihua Zhang;Xiang Cong(Department of Ultrasonography,Cheeloo Hospital of Shandong University,Jinan 250012,China;Perinatal Diagnosis Center,Cheeloo Hospital of Shandong University,Jinan 250012,China;Department of Biostatistics,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2023年第8期664-668,共5页
Chinese Journal of Perinatal Medicine
关键词
羊水
Γ-谷氨酰转移酶
胆道闭锁
超声检查
产前
Amniotic fluid
gamma-Glutamyltransferase
Biliary atresia
Ultrasonography,prenatal
