摘要
目的研究幽门螺旋杆菌(Hp)与非酒精性脂肪性肝病(NAFLD)的关系,并观察根除Hp前后代谢指标变化。方法选取秦皇岛军工医院进行体检的490例患者,分为NAFLD组127例及对照组363例。比较两组的一般资料及血清学指标,多因素logistic回归分析NAFLD的影响因素,同时观察治疗前后糖脂代谢情况。结果NAFLD组体质指数(25.36±2.97)kg/m^(2),对照组体质指数(21.53±2.62)kg/m^(2)(t=13.685,P<0.001);NAFLD组合并高血压30例(23.62%),对照组合并高血压24例(6.61%)(χ^(2)=27.763,P<0.001);NAFLD组丙氨酸氨基转移酶(31.03±22.56)U/L,对照组(17.15±12.25)U/L(t=8.641,P<0.001);NAFLD组天冬氨酸氨基转移酶(23.24±11.67)U/L,对照组(17.97±7.52)U/L(t=5.821,P<0.001);NAFLD组低密度脂蛋白胆固醇(2.84±0.84)mmol/L,对照组(2.52±0.68)mmol/L(t=4.283,P<0.001);NAFLD组高密度脂蛋白胆固醇(1.20±0.27)mmol/L,对照组(1.61±0.39)mmol/L(t=10.960,P<0.001);NAFLD组总胆固醇(5.11±1.02)mmol/L,对照组(4.69±0.93)mmol/L(t=4.270,P<0.001);NAFLD组三酯酰甘油(2.38±1.81)mmol/L,对照组(1.30±0.95)mmol/L(t=8.510,P<0.001);NAFLD组空腹血糖(4.98±1.28)mmol/L,对照组(4.49±0.96)mmol/L(t=4.518,P<0.001);NAFLD组Hp感染54例(42.52%),对照组112例(30.85%)(χ^(2)=5.716,P=0.017)。Logistic分析显示,体质指数(OR=4.125,95%CI:1.792~9.495)、高血压(OR=3.793,95%CI:1.836~7.836)、丙氨酸氨基转移酶(OR=3.412,95%CI:1.625~7.164)、天冬氨酸氨基转移酶(OR=3.314,95%CI:1.568~7.004)、低密度脂蛋白胆固醇(OR=2.506,95%CI:1.307~4.805)、高密度脂蛋白胆固醇(OR=2.741,95%CI:1.110~6.769)、总胆固醇(OR=3.644,95%CI:1.194~11.121)、三酯酰甘油(OR=2.815,95%CI:1.246~6.360)、空腹血糖(OR=3.488,95%CI:1.712~7.106)、Hp感染(OR=3.073,95%CI:1.429~6.608)是NAFLD患病的影响因素(P<0.05)。根除Hp治疗后NAFLD合并Hp感染患者的空腹血糖、空腹胰岛素、胰岛素抵抗指数、总胆固醇、三酯酰甘油、低密度脂蛋白胆固醇分别为(6.17±0.69)mmol/L、(7.66±1.34)μIU/m
Objective To study on the relationship between Helicobacter pylori(Hp)infection and non-alcoholic liver disease(NAFLD),and to observe the changes of metabolic parameters before and after Hp eradication.Methods A total of 490 patients who underwent physical examination in Qinhuangdao Military Hospital were divided into a NAFLD group(N=127 cases)and a control group(N=363 cases).The general data and serological indicators of these two groups were compared.The influencing factors of NAFLD were analyzed by Logistic regression,and the metabolisms of glucose and lipid were observed before and after the eradication treatment of Hp.Results The body mass index was(25.36±2.97)kg/m^(2)in the NAFLD group,and(21.53±2.62)kg/m^(2)in the control group(t=13.685,P<0.001).There were 30 cases(23.62%)of hypertension in the NAFLD group and 24 cases(6.61%)of hypertension in the control group(χ^(2)=27.763,P<0.001).The alanine aminotransferase level was(31.03±22.56)U/L in the NAFLD group and(17.15±12.25)U/L in the control group(t=8.641,P<0.001).The glutamic oxaloacetic transaminase level was(23.24±11.67)U/L in the NAFLD group and(17.97±7.52)U/L in the control group(t=5.821,P<0.001).The level of LDL cholesterol was(2.84±0.84)mmol/L in the NAFLD group and(2.52±0.68)mmol/L in the control group(t=4.283,P<0.001).The level of high density lipoprotein cholesterol was(1.20±0.27)mmol/L in the NAFLD group and(1.61±0.39)mmol/L in the control group(t=10.960,P<0.001).The total cholesterol level was(5.11±1.02)mmol/L in the NAFLD group and(4.69±0.93)mmol/L in the control group(t=4.270,P<0.001).Triacylglycerol level was(2.38±1.81)mmol/L in the NAFLD group and(1.30±0.95)mmol/L in the control group(t=8.510,P<0.001).The fasting blood glucose was(4.98±1.28)mmol/L in the NAFLD group,and(4.49±0.96)mmol/L in the control group(t=4.518,P<0.001).There were 54 cases(42.52%)of Hp infection in the NAFLD group and 112 cases(30.85%)in the control group(χ^(2)=5.716,P=0.017).Logistic regression analysis showed that body mass index(OR=4.125,95%CI:1.792~9
作者
王媛媛
李潇萌
丁秀婷
WANG Yuan-yuan;LI Xiao-meng;DING Xiu-ting(Department of Gastroenterology,Qinhuangdao Military Industry Hospital,Hebei 066000,China)
出处
《肝脏》
2023年第7期814-817,822,共5页
Chinese Hepatology
基金
秦皇岛市科技局项目(202101A210)。
