摘要
静脉血栓栓塞症(venous thromboembolism,VTE)是特发性膜性肾病(idiopathic membranous nephropathy,IMN)患者常见的并发症之一,是导致IMN患者死亡的重要因素。现有研究提示:高凝状态、血小板的异常激活、抗凝和凝血及纤溶系统失衡、内皮损伤和糖皮质激素的应用等因素是导致VTE发生的主要原因,炎症介质和免疫系统的调节对于VTE的发展也至关重要。目前关于IMN患者并发VTE机制的探究是广泛的,本文汇总近年国内外相关研究进展,对IMN合并VTE的发病机制进行综合阐述,为IMN患者的血栓预防及治疗提供理论支持。
Venous thromboembolism(VTE)is one of the common complications in patients with idiopathic membranous nephropathy(IMN)and is an important factor in the death of patients with IMN.Existing studies suggest that factors such as hypercoagulable state,abnormal activation of platelets,anticoagulation and coagulation and fibrinolytic system imbalance,endothelial injury,and glucocorticoid use are the main causes of VTE,and inflammatory mediators and immune system regulation are also crucial for the development of VTE.At present,the mechanism of VTE complicated by IMN patients is extensive,and this article summarizes the relevant research progress at home and abroad in recent years,and comprehensively elaborates the pathogenesis of IMN combined with VTE so as to provide theoretical support for thromboprevention and treatment in IMN patients.
作者
李安壮
梁黎明
许冬梅
LI Anzhuang;LIANG Liming;XU Dongmei(Department of Nephrology,The First Affiliated Hospital of Shandong First Medical University,Jinan 250014,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
CAS
2023年第8期603-607,共5页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
基金
国家自然科学基金面上项目(81970615)。
关键词
特发性膜性肾病
静脉血栓栓塞
高凝状态
idiopathic membranous nephropathy
venous thromboembolism
hypercoagulable state
