摘要
慢性咳嗽指发病时间>8周的不明原因的咳嗽,是临床最常见的疾病之一。全球成人慢性咳嗽发病率为9.6%。近些年来,咳嗽的发病机制、诊断及治疗的研究取得了很多新的进展,其中有一些新的检查手段应用于慢性咳嗽病因诊断中。呼出气一氧化氮(FeNO)、肺泡气一氧化氮(CaNO)通过反映气道炎症对慢性咳嗽病因进行诊断,而支气管肺泡灌洗液(BALF)细胞学分类则通过反映亚段支气管以下外周小气道和肺泡的炎症水平来参与慢性咳嗽病因的鉴别诊断。FeNO、CaNO及BALF细胞学分类联合诊断可以为慢性咳嗽病因诊断提供新的思路。本文主要对目前FeNO、CaNO及BALF细胞学分类在慢性咳嗽中的研究进行分析,并对未来慢性咳嗽的精准病因诊断提供思路。
Chronic cough,the onset of more than 8 weeks of unexplained cough,is one of the most common respiratory diseases.The global incidence of chronic cough in adults is 9.6%.In recent years,many new advances have been made in the diagnosis,treatment,and pathogenesis of cough,among which some new methods have been applied to the etiology diagnosis of chronic cough.Fractional exhaled nitric oxide(FeNO)and concentration of alveolar nitric oxide(CaNO)are involved in the differential diagnosis of the cause of chronic cough by reflecting airway inflammation;bronchoalveolar lavage fluid(BALF)cytological classification is involved by reflecting the level of inflammation in the peripheral small airways and alveoli below the subbronchi.The combined use of FeNO,CaNO,and BALF cytological classification can provide a new way to find the etiology of chronic cough.This article mainly reviews the current research on FeNO,CaNO,and BALF cytological classification in chronic cough,so as to provide new method for the precise etiological diagnosis of chronic cough in the future.
作者
汪晗希
方思
李传香
彭玉洁
高杏林
郭红荣
Wang Hanxi;Fang Si;Li Chuanxiang;Peng Yujie;Gao Xinglin;Guo Hongrong(Medical College of Wuhan University of Science and Technology,Wuhan 430065,China;Department of Respiratory and Critical Care Medicine,Wuhan Third Hospital,Tongren Hospital of Wuhan University,Wuhan 430060,China)
出处
《国际呼吸杂志》
2023年第8期891-896,共6页
International Journal of Respiration
基金
武汉市医学科研项目(WX20Q28)。
关键词
气道炎症
呼出气一氧化氮
肺泡气一氧化氮
支气管肺泡灌洗液
慢性咳嗽
Airway inflammation
Fractional exhaled nitric oxide
Alveolar nitric oxide
Bronchoalveolar lavage fluid
Chronic cough
