摘要
目的观察青鹏软膏联合针刺推拿治疗青藏地区膝骨关节炎(KOA)患者的临床效果。方法选取2021年3月至2022年3月青海省人民医院门诊收治的KOA患者80例,按照随机数字表法分为对照组和观察组,各40例。对照组给予口服硫酸氨基葡萄糖片;观察组给予青鹏软膏联合针刺推拿治疗。比较2组患者治疗前、治疗后、停止治疗3个月后血清炎症因子白细胞介素1β(IL-1β)、IL-6、肿瘤坏死因子α(TNF-α)水平,患侧膝关节视觉模拟量表(VAS)疼痛评分、Lysholm膝关节功能评分、患膝关节被动屈曲度(PROM)。比较2组患者临床疗效。结果治疗后,观察组IL-6水平低于对照组,差异有统计学意义(P<0.05)。停止治疗3个月后,观察组IL-1β、IL-6、TNF-α水平均低于对照组,差异均有统计学意义(均P<0.05)。治疗后及停止治疗3个月后观察组患侧膝关节VAS疼痛评分低于对照组、Lysholm膝关节功能评分高于对照组,患膝关节PROM大于对照组(均P<0.05)。治疗后,2组总有效率比较差异无统计学意义(P>0.05)。停止治疗3个月后,观察组总有效率明显高于对照组[95.0%(38/40)比52.5%(21/40)](P<0.05)。结论青鹏软膏联合针刺推拿治疗KOA短期疗效明显,长期疗效维持较好,能有效缓解患者膝关节痛和活动功能障碍。
Objective To observe the clinical effect of Qingpeng ointment combined with acupuncture and massage in treating knee osteoarthritis(KOA)patients in the Qinghai-Tibet region.Methods From March 2021 to March 2022,80 patients with KOA admitted to the outpatient clinic of Qinghai Provincial People′s Hospital were selected.They were divided into control and observation groups according to the random number table method,with 40 cases in each group.The control group was given oral glucosamine sulfate tablets,and the observation group was given Qingpeng ointment combined with acupuncture and massage treatment.The levels of serum inflammatory factor interleukin-1β(IL-1β),IL-6,tumour necrosis factorα(TNF-α),visual analog scale(VAS)pain score of the affected knee joint,Lysholm knee function score,and degree of passive flexion(PROM)of the affected knee joint were compared between the two groups before treatment,after treatment,and 3 months after cessation of treatment.Clinical efficacies were compared between the two groups.Results After treatment,the level of IL-6 in the observation group was lower than that in the control group(P<0.05).Three months after cessation of treatment,the levels of IL-1β,IL-6,TNF-αin the observation group were lower than those in the control group(all P<0.05).After treatment and 3 months after cessation of treatment,VAS pain score of the affected knee joint in the observation group was lower than that in the control group,Lysholm knee function score was higher than that in the control group,and PROM of the affected knee joint was greater than that in the control group(all P<0.05).After treatment,there was no statistically significant difference in the total effective rate between the two groups(P>0.05).Three months after cessation of treatment,the total effective rate in the observation group was significantly higher than that in the control group[95.0%(38/40)vs 52.5%(21/40)](P<0.05).Conclusion Qingpeng ointment combined with acupuncture and massage in treating KOA has obvious short-term e
作者
保善录
赵亮
祁永红
陈鲜霞
高彤
赵秀红
唐纯志
Bao Shanlu;Zhao Liang;Qi Yonghong;Chen Xianxia;Gao Tong;Zhao Xiuhong;Tang Chunzhi(Department of Integrated Traditional Chinese and Western Medicine,Qinghai Provincial People′s Hospital,Xining 810000,China;Department of Imaging,Qinghai Provincial People′s Hospital,Xining 810000,China;Department of Ultrasound,Qinghai Provincial People′s Hospital,Xining 810000,China;Clinical Medical College of Acupuncture Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)
出处
《中国医药》
2023年第9期1396-1400,共5页
China Medicine
基金
青海省卫生健康委员会指导项目(2019-wjzdx-43)。
关键词
膝骨关节炎
青鹏软膏
针刺
推拿
Knee osteoarthritis
Qingpeng ointment
Acupuncture
Massage
