摘要
目的探讨依折麦布联合尼可地尔治疗老年冠心病的临床效果。方法选取2019年3月至2021年4月我院收治的102例老年冠心病患者作为研究对象,根据治疗方案不同将其分为对照组和观察组,各51例。对照组给予尼可地尔治疗,观察组在对照组基础上给予依折麦布治疗。比较两组的临床疗效、血小板活化功能指标、可溶性细胞间黏附分子-1(sICAM-1)、血管内皮生长因子(VEGF)水平、全血低切黏度、全血高切黏度、血浆黏度、红细胞压积及纤维蛋白原水平。结果观察组的治疗总有效率为92.16%,高于对照组的76.47%,差异具有统计学意义(P<0.05)。治疗后,观察组的溶酶体膜糖蛋白(CD63)、血小板表面α-颗粒膜糖蛋白(CD62p)、血小板聚集率(PAR)低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的sICAM-1水平低于对照组,VEGF水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的全血低切黏度、全血高切黏度、血浆黏度、红细胞压积及纤维蛋白原水平低于对照组,差异具有统计学意义(P<0.05)。结论依折麦布联合尼可地尔治疗老年冠心病的效果显著,可改善血小板活化功能,调节sICAM-1、VEGF水平。
Objective To investigate the clinical effect of ezetimibe combined with nicorandil in the treatment of elderly patients with coronary heart disease.Methods A total of 102 elderly patients with coronary heart disease admitted in our hospital from March 2019 to April 2021 were selected as the research objects,and the patients were divided into control group and observation group according to different treatment schemes,with 51 cases in each group.The control group was treated with nicorandil,and the observation group was treated with ezetimibe on the basis of the control group.The clinical efficacy,platelet activation function indexes,soluble intercellular adhesion molecule-1(sICAM-1),vascular endothelial growth factor(VEGF)levels,whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,hematocrit and fibrinogen level were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.16%,which was higher than 76.47%in the control group,and the difference was statistically significant(P<0.05).After treatment,the lysosome intact membrane protein(CD63),alpha-granular membrane protein(CD62p)and platelet aggregation rate(PAR)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the level of sICAM-1 in the observation group was lower than that in the control group,the level of VEGF was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,hematocrit and fibrinogen level in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Ezetimibe combined with nicorandil in the treatment of elderly patients with coronary heart disease has a significant effect,it can improve platelet activation function and regulate the levels of sICAM-1 and VEGF.
作者
刘涛
徐凡叶
LIU Tao;XU Fanye(Xi'an Daxing Hospital,Xi'an 710016,China)
出处
《临床医学研究与实践》
2023年第25期46-49,共4页
Clinical Research and Practice
关键词
依折麦布
尼可地尔
老年
冠心病
血小板活化功能
可溶性细胞间黏附分子-1
血管内皮生长因子
ezetimibe
nicorandil
elderly
coronary heart disease
platelet activation function
soluble intercellular adhesion molecule-1
vascular endothelial growth factor
