摘要
原发性牙齿萌出障碍(PFE)是一种罕见的常染色体显性遗传性疾病,主要表现为单侧或双侧后牙区开,无明显局部阻碍因素和全身因素,主要与患者牙齿萌出机制异常有关。目前研究认为其病因与甲状旁腺激素受体1(PTH1R)基因突变有密切联系,但其背后的致病机制还有待阐明。本文就与PFE发病相关的热点基因PTH1R信号缺陷与破骨细胞功能、牙囊发育、牙槽骨形成、牙周膜形成、牙根形成的研究现状进行综述,意为PFE的病因遗传学及分子机制的研究提供参考。
Primary failure of eruption(PFE)is a rare autosomal dominant hereditary disease mainly characterized by unilateral or bilateral posterior tooth open bite and absence of obvious local hindrance or systemic factors.PFE is related to the abnormal mechanism of tooth eruption.Its etiology is closely related to the mutation of parathyroid hormone receptor 1(PTH1R)gene,but the underlying mechanism remains to be elucidated.This article reviews the research status of hot gene PTH1R signal defects related to the pathogenesis of PFE and osteoclast function,dental follicle development,alveolar bone formation,periodontal ligament formation,and root formation,to provide reference for the study of etiological genetics and molecular mechanism of PFE.
作者
余岳霖
孔卫东
Yu Yuelin;Kong Weidong(School of Stomatology,Jinan University,Guangzhou 510630,China;Dept.of Orthodontics,The First Affiliated Hospital of Jinan University,Guangzhou 510630,China)
出处
《国际口腔医学杂志》
CAS
CSCD
2023年第5期573-580,共8页
International Journal of Stomatology
基金
暨南大学附属第一医院临床前沿新技术项目(JNU1AFCFTP-2022-a01229)。
关键词
原发性牙齿萌出障碍
甲状旁腺激素受体1
破骨细胞
牙囊
牙槽骨
牙周膜
primary failure of eruption
parathyroid hormone receptor 1
osteoclast
dental follicle
alveolar bone
periodontal ligament
