摘要
β-catenin是经典Wnt信号通路的核心分子,其在牙的发生发育中发挥重要的调控作用。本文从β-catenin在牙发育过程中的表达分布特点以及在牙发生、牙冠发育、牙根形成中的作用机制等方面,对近年来的相关研究进展进行综述,以期为阐明牙发育机制、探索牙发育相关疾病的潜在治疗靶点以及精准调控牙再生提供新的思路。
β-catenin is the central hub in the canonical Wnt/β-catenin signaling pathway,which plays an important role in the regulation of odontogenesis and tooth development.In this paper,we reviewed the recent research progress in terms of the expression pattern ofβ-catenin during tooth development,the molecular mechanism ofβ-catenin in tooth development process which includes odontogenesis,crown development and root formation.It may provide a reference for elucidation of tooth development mechanism,exploration of potential therapeutic targets of tooth development related diseases,and precise regulation of tooth regeneration.
作者
隋昕
杜仲
SUI Xin;DU Zhong(Department of Endodontics,Shanghai Stomatological Hospital&School of Stomatology,Fudan University,Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Fudan University,Shanghai 200031;Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai 200011,China)
出处
《中国口腔颌面外科杂志》
CAS
2023年第4期413-417,共5页
China Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金(82201085)。
