摘要
牙的发育是一个长期复杂的生物学过程,包括牙胚的发生、组织形成和牙的萌出,分为牙冠的发育和牙根的发育,牙根的发育开始于牙冠形成之后,是由上皮和外胚间充质组织共同调控完成的,且包括牙本质及牙骨质的发育。近几十年来学者们进行了大量的实验研究,对牙冠的发育机制已有了深入的了解,而对牙根的发育机制知之甚少。牙源性干细胞的发现推动了牙组织工程的进展,其与牙根发育联系紧密,而具体机制尚未明确。本文对近年来牙根发育机制的研究进展及其与牙源性干细胞的联系做一综述。
Tooth development is a long-term and complicated biological process which includes the occurrence of tooth germs,the formation of dental tissues and the eruption of the tooth.It includes the development of the crown and the root.After the formation of the tooth crown,the development of the tooth begins.It is regulated by the epithelial and the ectodermal mesenchymal tissues,including the development of the dentin and the cementum.In recent decades,scholars carried out a large number of experimental studies of the development mechanism of the crown.And it has been in-depth understanding.However,the regulatory mechanism of the root is poorly understood.Recently,the discovery of dental stem cells has promoted the progress of dental tissue engineering.It is also closely related to root development.However,the mechanism is still unclear.This article reviews the development mechanism of the root and the relationship between root development and dental stem cells.
作者
李燕玲
陈柯
LI Yanling;CHEN Ke(School of Stomatology Medical,Jinan University,Guangzhou 510000,China;Stomatology Hospital of Southern Medical University,Guangzhou 510000,China)
出处
《分子影像学杂志》
2019年第1期91-94,共4页
Journal of Molecular Imaging
基金
广州市科技计划项目(201510010160)
关键词
牙根发育
信号通路
分子机制
牙源性干细胞
牙根再生
root development
signaling pathway
molecular mechanism
odontogenic stem cells
root regeneration
