摘要
目的分析胃溃疡患者幽门螺杆菌(Hp)血清学抗体及胃肠激素表达与患者病理特征的关系。方法118例胃溃疡患者为胃溃疡组,同期的80例健康体检者为对照组,比较2组受试者Hp感染情况及胃溃疡类型(Ⅰ型、中间型及Ⅱ型),比较2组受试者Hp感染血清学抗体[细胞毒素相关蛋白A(CagA)、空泡毒素A(VacA)、尿素酶A(UreA)、尿素酶B(UreB)]阳性检出率及血清胃肠激素[胃泌素(GAS)、生长抑素(SS)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)]水平,探讨胃溃疡患者Hp感染与血清胃肠激素水平的关系,分析胃溃疡患者Hp感染血清学抗体检出率、血清胃肠激素水平与胃溃疡病理特征的关系。结果胃溃疡组Ⅰ型Hp感染阳性检出率高于对照组,差异有统计学意义(P<0.05);胃溃疡组血清CagA、VacA、UreA及UreB阳性检出率均高于对照组(P<0.05),血清GAS、PGⅠ水平均较对照组升高、SS水平较对照组降低(P<0.05);胃溃疡Hp感染阳性患者血清GAS、PGⅠ及PGⅡ水平高于阴性患者,血清SS水平低于阴性患者(P<0.05);溃疡面积>2 cm^(2)、炎症活动性中重度、恶性溃疡CagA阳性率较高,溃疡面积>2 cm^(2)、恶性溃疡患者中VacA阳性率较高,溃疡面积>2 cm^(2)患者中UreA、UreB阳性率均较高(P<0.05);溃疡面积>2 cm^(2)患者血清GAS、PGⅠ水平较溃疡面积≤2 cm^(2)患者升高(P<0.05),SS较溃疡面积≤2 cm^(2)患者下降(P<0.05);炎症活动性中重度患者血清GAS、PGⅠ水平较轻度患者升高(P<0.05),SS较轻度患者下降(P<0.05);恶性溃疡患者血清SS、PGⅠ表达较良性患者下降(P<0.05),PGⅡ较良性患者升高(P<0.05)。结论胃溃疡患者Ⅰ型Hp感染阳性检出率较高,患者存在血清胃肠激素水平异常,Hp感染血清学抗体阳性检出率及胃肠激素水平均与胃溃疡病理特征有关。
Objective To analyze the relationship between serum antibodies against Helicobacter pylori(Hp),gastrointestinal hormone expression,and pathological characteristics in patients with gastric ulcers.Methods A total of 118 patients with gastric ulcers were included in the gastric ulcer group,while 80 healthy individuals undergoing health check-ups were selected as the control group.The Hp infection status and gastric ulcer types(typeⅠ,intermediate,and typeⅡ)were compared between the two groups.The positive detection rates of serum antibodies against Hp infection[Cytotoxin Associated Protein A(CagA),Vacuolating cytotoxin A(VacA),Urease A(UreA),and Urease B(UreB)]were compared,along with the serum levels of gastric hormones[Gastrin(GAS),Somatostatin(SS),PepsinogenⅠ(PGⅠ),and PepsinogenⅡ(PGⅡ)].The relationship between Hp infection and serum levels of gastric hormones in patients with gastric ulcers was explored.Additionally,the relationship between the positive detection rate of serological antibodies against Hp infection,serum hormone levels,and pathological characteristics of gastric ulcers was analyzed.Results The positive detection rate of typeⅠHp infection was higher in the gastric ulcer group compared to the control group,with statistical significance(P<0.05).The gastric ulcer group exhibited higher positive detection rates of serum antibodies(CagA,VacA,UreA,and UreB)and higher levels of serum GAS and PGⅠcompared to the control group(P<0.05).Conversely,the levels of serum SS were lower in the gastric ulcer group compared to the control group(P<0.05).Within the gastric ulcer group,patients with positive Hp infection had higher serum levels of GAS,PGⅠ,and PGⅡ,and lower levels of SS compared to negative patients(P<0.05).Furthermore,patients with larger ulcer areas(>2 cm^(2)),moderate to severe inflammatory activity,and malignant ulcers had higher positive rates of specific antibodies(CagA,VacA,UreA,and UreB;P<0.05).Increased levels of serum GAS and PGⅠwere observed in patients with larger ulcer a
作者
樊景云
姚勇
奉镭
潘金
罗兰
FAN Jingyun;YAO Yong;FENG Lei;PAN Jin;LUO Lan(Digestive Ward Five,Suining Central Hospital,Suining 629000,Sichuan,China)
出处
《贵州医科大学学报》
CAS
2023年第8期956-962,共7页
Journal of Guizhou Medical University
基金
四川省卫生健康委员会科研课题(20PJ286)。
关键词
胃溃疡
胃镜
幽门螺杆菌
血清学抗体
胃肠激素
病理特征
gastric ulcer
gastroscopy
helicobacter pylori
serological antibodies
gastrointestinal hormones
pathological characteristics
