摘要
目的:研究重组人粒细胞集落刺激因子(rhG-CSF)皮下注射联合常规治疗对复发性流产(RSA)患者妊娠结局的影响。方法:选取2019年1月-2022年1月贵阳市第一人民医院收治的100例RSA患者,按照单双号法随机分为对照组(单号,n=50,进行常规治疗)和观察组(双号,n=50,在对照组基础上予以rhG-CSF皮下注射治疗)。比较两组的妊娠率、流产率、活产率及人绒毛膜促性腺激素(hCG)、血清可溶性fms样酪氨酸激酶1(sFlt-1)、血管内皮生长因子(VEGF)、胎盘生长因子(PLGF)水平变化,统计比较两组治疗期间不良反应发生情况。结果:治疗后,观察组妊娠率和总活产率明显高于对照组,差异有统计学意义(P<0.05)。妊娠8周,观察组活产患者hCG水平高于对照组,差异有统计学意义(P<0.05);妊娠16周,两组活产患者PLGF水平高于妊娠12周,sFlt-1及s Flt-1/PLGF低于妊娠12周,且观察组活产患者PLGF水平高于对照组,sFlt-1及sFlt-1/PLGF低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:rhG-CSF皮下注射联合常规治疗可有效降低RSA患者流产率,提高活产率,安全有效。
Objective:To study the effects of subcutaneous injection of Recombinant Human Granulocyte Colony-stimulating Factor(rhG-CSF)combined with conventional therapy on pregnancy outcomes in patients with recurrent spontaneous abortion(RSA).Method:A total of 100 patients with RSA admitted to the First People's Hospital of Guiyang from January 2019 to January 2022 were selected,and they were randomly divided into control group(odd number,n=50,treated with conventional therapy)and observation group(even number,n=50,treated with rhG-CSF subcutaneous injection on the basis of control group)according to the odd-even number method.The clinical pregnancy rate,abortion rate,live birth rate,and the levels of human chorionic gonadotropin(hCG),serum soluble fms-like tyrosine kinase-1(sFlt-1),vascular endothelial growth factor(VEGF),placental growth factor(PLGF)were compared,and the adverse reactions in the two groups during treatment were counted.Result:After treatment,the pregnancy rate and total live birth rate in observation group were significantly higher than those in control group,the differences were statistically significant(P<0.05).At 8 weeks of pregnancy,the hCG levels of live birth patients in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).At 16 weeks of pregnancy,the PLGF levels in the two groups of live birth patients were higher than those at 12 weeks of pregnancy,while sFlt-1 and sFlt-1/PLGF were lower than those at 12 weeks of pregnancy;and the PLGF levels in the observation group of live birth patients was higher than that in the control group,while the sFlt-1 and sFlt-1/PLGF levels were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of rhG-CSF subcutaneous injection and conventional treatment can effectively reduce the abortion rate and improve the live bi
作者
吴孝凤
翁爱丽
宋朝晖
WU Xiaofeng;WENG Aili;SONG Zhaohui(The First People's Hospital of Guiyang,Guiyang 450000,China;不详)
出处
《中外医学研究》
2023年第23期126-129,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
重组人粒细胞集落刺激因子
复发性流产
活产率
激素水平
Recombinant Human Granulocyte Colony-stimulating Factor
Recurrent spontaneous abortion
Live birth rate
Hormones levels
