摘要
目的:探讨不同病情严重程度急性肺栓塞(APE)患者血清和肽素、白细胞介素-38(IL-38)、单核细胞计数/高密度脂蛋白胆固醇(MHR)、D-二聚体/纤维蛋白原(DFR)的变化,分析患者预后影响因素。方法:选取APE患者80例,根据病情严重程度不同分为低危组(35例)、中危组(28例)和高危组(17例)。另选取同期体检健康者50例为对照组。比较各组血清和肽素、IL-38、MHR、DFR水平。采用肯德尔秩相关分析血清和肽素、IL-38、MHR、DFR水平与疾病严重程度的相关性。根据预后情况将APE患者分为生存组(66例)和病死组(14例),分析APE患者预后的影响因素。结果:与对照组比较,低、中、高危组血清和肽素、MHR、DFR水平升高,IL-38水平降低(均P<0.05)。中、高危组血清和肽素、MHR、DFR水平高于低危组,且高危组高于中危组(均P<0.05)。中、高危组IL-38水平低于低危组,且高危组低于中危组(均P<0.05)。和肽素与APE患者病情严重程度呈正相关(r=0.230,P=0.009),IL-38、MHR、DFR水平与病情严重程度无关(均P>0.05)。病情严重程度(高危)、BNP>100 pmol/L、cTnT>0.2μg/L、和肽素、MHR、DFR为APE患者预后的独立危险因素,IL-38则是独立保护因素(均P<0.05)。结论:APE患者血清和肽素、MHR、DFR水平随病情加重而升高,IL-38水平随病情加重而降低。病情严重程度、BNP、cTnT、和肽素、IL-38、MHR、DFR为APE患者预后的独立影响因素。
Objective:To investigate the changes of serum copeptin,interleukin-38(IL-38),monocyte to high-density lipoprotein cholesterol ratio(MHR),and D-dimer to fibrinogen ratio(DFR)in patients with acute pulmonary embolism(APE)of different severity,and to analyze the prognostic factors of patients.Methods:According to the severity of the disease,80 patients with APE were divided into low-risk group(35 cases),medium-risk group(28 cases)and high-risk group(17 cases).Another 50 healthy people were selected as the control group.The levels of serum copeptin,IL-38,MHR and DFR in each group were compared.Kendall rank correlation was used to analyze the correlation between serum copeptin,IL-38,MHR,DFR levels and the severity of the disease.According to the prognosis,the APE patients were divided into survival group(66 cases)and death group(14 cases),and the prognostic factors of APE patients were analyzed.Results:Compared with the control group,the levels of serum copeptin,MHR and DFR in the low-,medium-and high-risk groups were increased,and the level of IL-38 was decreased(all P<0.05).The levels of serum copeptin,MHR and DFR in the medium-and high-risk groups were higher than those in the low-risk group,and those in the high-risk group were higher than those in the medium-risk group(all P<0.05).The level of IL-38 in the medium-and high-risk groups was lower than that in the low-risk group,and the high-risk group was lower than that in the medium-risk group(all P<0.05).Copeptin was positively correlated with the severity of APE patients(r=0.230,P=0.009),while IL-38,MHR and DFR levels were not correlated with the severity of APE patients(all P>0.05).The severity of disease(high-risk),BNP>100 pmol/L,cTnT>0.2μg/L,copeptin,MHR and DFR were independent risk factors for the prognosis of APE patients,and IL-38 was an independent protective factor(all P<0.05).Conclusion:The levels of serum copeptin,MHR and DFR in patients with APE increase with the aggravation of the disease,while the level of IL-38 decreases.The severity of the disea
作者
赵贺红
李群
ZHAO Hehong;LI Qun(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Southwest Jiaotong University,Chengdu 610031,China)
出处
《陕西医学杂志》
CAS
2023年第9期1186-1190,共5页
Shaanxi Medical Journal
基金
四川省医学会科研课题(2021HR78)。
