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稳心颗粒联合胺碘酮在冠心病心律失常治疗中的应用效果分析

Effect analysis of Wenxin granule combined with amiodarone in the treatment of arrhythmia in coronary heart disease
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摘要 目的研究稳心颗粒联合胺碘酮在冠心病心律失常治疗中的应用效果。方法100例冠心病心律失常患者,随机分为观察组和对照组,每组50例。观察组患者采取稳心颗粒联合胺碘酮治疗,对照组患者采取胺碘酮治疗。比较两组患者治疗效果、不良反应发生情况及治疗前后血流动力学指标(纤维蛋白原、血浆粘度、血细胞比容)、心功能指标[左室射血分数(LVEF)、左室短轴缩短率(FS)、心率]、心律失常指标(室性期前收缩、房性期前收缩次数)。结果观察组患者治疗总有效率为98.00%,高于对照组的80.00%,差异具有统计学意义(P<0.05)。治疗后,两组患者纤维蛋白原、血浆粘度、血细胞比容均低于本组治疗前,且观察组患者纤维蛋白原(4.34±1.99)g/L、血浆粘度(1.10±0.02)mPa·s、血细胞比容(32.22±1.09)%低于对照组的(7.45±2.99)g/L、(1.89±0.23)mPa·s、(44.56±1.87)%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为2.00%,低于对照组的28.00%,差异具有统计学意义(P<0.05)。治疗后,两组患者LVEF、FS高于本组治疗前,心率低于本组治疗前,且观察组患者LVEF(57.78±1.82)%、FS(35.56±1.12)%高于对照组的(52.33±1.63)%、(24.09±1.05)%,心率(69.45±1.73)次/min低于对照组的(81.20±1.28)次/min,差异具有统计学意义(P<0.05)。治疗后,两组患者室性期前收缩、房性期前收缩次数少于本组治疗前,且观察组患者室性期前收缩次数(698.11±50.21)次/d、房性期前收缩次数(291.27±41.26)次/d少于对照组的(890.21±97.87)、(483.25±89.84)次/d,差异具有统计学意义(P<0.05)。结论稳心颗粒联合胺碘酮在冠心病心律失常治疗中具有显著疗效,能够促进患者血流动力学、心功能改善,且安全性高,值得推广应用。 Objective To study the effect of Wenxin granule combined with amiodarone in the treatment of arrhythmia in coronary heart disease.Methods A total of 100 cases of coronary heart disease patients with arrhythmia were randomly divided into observation group and control group,with 50 cases in each group.The observation group was treated with Wenxin granule and amiodarone,and the control group was treated with amiodarone.Both groups were compared in terms of therapeutic effect,occurrence of adverse reactions,hemodynamic indexes(fibrinogen,plasma viscosity,hematocrit),cardiac function indexes[left ventricular ejection fraction(LVEF),fractional shortening rate(FS),heart rate]and arrhythmia indexes(number of ventricular premature contraction and atrial premature contraction).Results The total effective rate of 98.00%in the observation group was higher than that of 80.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the fibrinogen,plasma viscosity and hematocrit in both groups were lower than those before treatment in this group;in the observation group,the fibrinogen was(4.34±1.99)g/L,the plasma viscosity was(1.10±0.02)mPa·s,and the hematocrit was(32.22±1.09)%,which were lower than those of(7.45±2.99)g/L,(1.89±0.23)mPa·s,and(44.56±1.87)%in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions of 2.00%in the observation group was lower than that of 28.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,LVEF and FS in both groups were higher than those before treatment in this group,and the heart rate was lower than that before treatment in this group;LVEF of(57.78±1.82)%and FS of(35.56±1.12)%in the observation group were higher than those of(52.33±1.63)%and(24.09±1.05)%in the control group;the heart rate of(69.45±1.73)beats/min in the observation group was lower than that of(81.20±1.28)beats/min in the control group;the differences were statistically significant(P
作者 朱婷 童有福 ZHU Ting;TONG You-fu(Department of Internal Medicine,Zhongzhai Central Hospital of Chengzhong District,Xining 810012,China)
出处 《中国现代药物应用》 2023年第16期14-17,共4页 Chinese Journal of Modern Drug Application
关键词 稳心颗粒 胺碘酮 冠心病心律失常 应用效果 Wenxin granule Amiodarone Arrhythmia in coronary heart disease Application effect
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