摘要
目的:分析地西他滨联合CAG方案治疗老年急性髓系白血病的临床效果。方法:选取2018年1月—2022年1月新泰市人民医院收治的40例老年急性髓系白血病(非急性早幼粒细胞白血病)患者作为研究对象,根据随机数字表法分为两组,各20例。对照组给予CAG方案治疗,试验组给予地西他滨联合CAG方案治疗。比较两组临床疗效、不良反应发生情况、造血能力、血清因子水平。结果:试验组治疗总有效率高于对照组,差异有统计学意义(P=0.025)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,两组红细胞计数、血红蛋白、血小板计数均高于治疗前,且试验组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血管内皮生长因子、碱性成纤维细胞生长因子、肿瘤相关物质群水平均低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。结论:地西他滨联合CAG方案治疗老年急性髓系白血病的效果确切,安全性高,可改善患者造血功能及血清因子水平。
Objective:To analyze the clinical effect of decitabine combined with CAG in the treatment of senile acute myeloid leukemia.Methods:From January 2018 to January 2022,40 elderly patients with acute myeloid leukemia(non-acute promyelocytic leukemia)admitted to the People's Hospital of Xin Tai City were selected as study subjects.They were divided into two groups according to the random number table method,with 20 cases in each group.The control group was treated with CAG,and the experimental group was treated with decitabine combined with CAG.The clinical efficacy,occurrence of adverse reactions,hematopoietic ability,and serum factor levels in the two groups were compared.Results:The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P=0.025).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,the red blood cell count,hemoglobin and platelet count in the two groups were higher than those before treatment,and the experimental group was higher than the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of vascular endothelial growth factor,basic fibroblast growth factor and tumor-related substances in the two groups were lower than those before treatment,and the experimental group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion:The effect of decitabine combined with CAG in the treatment of senile acute myeloid leukemia is definite and safe,and it can improve hematopoietic function and serum factor levels in patients.
作者
翟立富
Zhai Lifu(Department of Hematology,Affiliated Hospital of Qilu Medical University(The People's Hospital of Xin Tai City),Xintai 271200,Shandong Province,China)
出处
《中国社区医师》
2023年第23期50-52,共3页
Chinese Community Doctors
