摘要
外泌体是由多种类型的细胞分泌的一类膜状囊泡,在正常和病理状态下进行着细胞间通信的功能。越来越多的报道显示外泌体,尤其是肝细胞来源的外泌体在非酒精性脂肪性肝病(NAFLD)/非酒精性脂肪性肝炎(NASH)的发生中发挥重要作用。本文从肝细胞脂肪变性、凋亡和炎症、纤维化等肝损伤来阐释肝源性外泌体的影响机制,以期为NAFLD/NASH机制研究提供参考。
Exosomes are membranous vesicles secreted by a variety of cell types,and carry out the function of intercellular communication under normal and pathological conditions.More and more reports suggest that exosomes,especially hepatocellular derived exosomes,play an important role in the development of non-alcoholic steatohepatitis(NAFLD)/non-alcoholic steatohepatitis(NASH).In this review,we elucidate the mechanism of hepatogenic exosomes from the perspectives of liver injuries such as liver lipid metabolism,apoptosis,inflammation,and fibrosis,in order to provide reference for the study of NAFLD/NASH mechanism.
作者
张卿
刘素彤
赵文霞(审校)
ZHANG Qing;LIU Sutong;ZHAO Wenxia(Henan University of Traditional Chinese Medicine,Zhengzhou,450046,China;Department of Hepatology and Spleen-Stomach,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine)
出处
《中国中西医结合消化杂志》
CAS
2023年第8期649-653,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金(No:82205086)
河南省特色骨干学科中医学学科建设项目(No:STG-ZYX02-202117)。
关键词
酒精性脂肪性肝病
肝源性外泌体
脂质代谢
non-alcoholic fatty liver disease
hepatocellular derived exosomes
lipid metabolism
