摘要
非酒精性脂肪性肝病相关肝细胞癌(NAFLD-HCC)的发病率逐渐上升。其发病机制与遗传和表观遗传修饰、代谢、免疫、肠道微生态、内分泌通路和昼夜节律的改变有关。总结了目前NAFLD-HCC发病机制的现有数据,认为多因素共同交互作用可引起HCC的发生。
The incidence rate of nonalcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) is gradually increasing. Its pathogenesis is associated with the changes in genetic and epigenetic modifications, metabolism, immunity, intestinal microecology, endocrine pathways, and circadian rhythm. This article summarizes the available data on the pathogenesis of NAFLD-HCC and points out that HCC is caused by the interactions between multiple factors.
作者
刘素彤
赵文霞
LIU Sutong;ZHAO Wenxia(Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第7期1621-1625,共5页
Journal of Clinical Hepatology
基金
河南省自然科学基金资助项目(162300410183)
关键词
非酒精性脂肪性肝病
肝肿瘤
病理过程
non-alcoholic fatty liver disease
liver neoplasms
pathologic processes
