摘要
目的 研究子宫动脉频谱形态异常联合血清CC趋化因子配体19(CCL19)水平预测系统性红斑狼疮(SLE)患者不良妊娠结局(APO)的价值。方法 选取2015年1月至2022年1月于青岛市妇女儿童医院治疗的妊娠合并SLE患者80例,根据妊娠结局将其分为APO组(34例)和Non-APO组(46例)。比较两组子宫动脉频谱形态、血清CCL19水平,分析两者与SLE患者APO的相关性及预测效能。结果 与Non-APO组相比,APO组子宫动脉频谱形态异常构成比、血清CCL19水平均升高(P <0.05)。Logistic风险回归分析显示,子宫动脉频谱形态、血清CCL19是SLE患者APO的危险因素(P <0.05)。ROC曲线显示,血清CCL19、预测SLE患者APO的最佳截断点为335.89 ng/L,AUC为0.816;子宫动脉频谱形态异常预测SLE患者APO的AUC为0.694;两者联合预测的AUC为0.858。结论 子宫动脉频谱形态异常、血清CCL19水平是SLE患者APO的危险因素,两者联合检测对其具有较高的预测效能。
Objective To investigate the value of morphological abnormalities of uterine artery on Doppler ultrasound combined with serum CC chemokine ligand 19(CCL19) level in predicting adverse pregnancy outcomes(APO) in patients with systemic lupus erythematosus(SLE).Methods Eighty pregnant women with SLE were selected from January 2015 to January 2022 in Qingdao Women and Children′s Hospital and divided into APO group(34 women) and non-APO group(46 women) according to their pregnancy outcomes.The morphology of uterine artery on Doppler ultrasound and serum CCL19 level were compared between the two groups.The correlation and predictive efficacy of the combined detection with APO in SLE patients were analyzed.Results As compared with non-APO group,APO group had an increase in morphological abnormalities of uterine artery and serum CCL19 level(P<0.05).Logistic risk regression showed that the morphology of uterine artery and serum CCL19were risk factors for APO in patients with SLE(P<0.05).The ROC curve showed that the optimal cut-off point for serum CCL19 to predict APO in patients with SLE was 335.89 ng/L,and the area under curve(AUC) for predicting APO in patients with SLE was 0.816.The AUC for morphological abnormalities of uterine artery on Doppler ultrasound to predict APO in patients with SLE was 0.694.The AUC for the combined prediction was 0.858.Conclusions Morphological abnormalities of uterine artery on Doppler ultrasound and serum CCL19 level are risk factors for APO in patients with SLE,and their combined detection has a higher predictive efficacy.
作者
刘羽
李宝来
邢倩
许茜
杨晨曦
LIU Yu;LI Baolai;XING Qian;XU Qian;YANG Chenxi(Department of Obstetrics,Qingdao Women and Children′s Hospital,Qingdao 266000,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2023年第15期1950-1955,共6页
The Journal of Practical Medicine
基金
山东省医药卫生科技发展计划项目(编号:202205020092)。
关键词
系统性红斑狼疮
不良妊娠结局
子宫动脉频谱形态异常
CC趋化因子配体19
systemic lupus erythematosus
adverse pregnancy outcome
morphological abnormalities of uterine artery on Doppler ultrasound
CC chemokine ligand 19
