摘要
目的使用中西医结合疗法治疗早期先兆流产,考察研究临床效果。方法收集2021年7月至2022年10月高密市人民医院就诊的早期先兆流产患者88例,采用随机数表法分为两组,每组各44例。两组均使用西医基础疗法,给予地屈孕酮片,研究组加用中药保胎方(党参、黄芪、熟地黄、菟丝子、丹参、桑寄生、钩藤、白术、黄芩、白芍、甘草),两组均以6 d为1个疗程,治疗2个疗程。制订疗效标准,检测治疗前后两组患者雌二醇、绒毛膜促性腺激素、孕激素血清激素水平,检查血清炎性因子白细胞介素-2、血清肿瘤坏死因子-α;多普勒超声监测胎儿发育情况,记录患者阴道出血、腹痛等症状改善情况。结果研究组、对照组总有效率分别为93.18%、79.54%,分别治愈34、25例,差异有统计学意义(P<0.05);治疗前两组患者血清激素水平和血清炎性因子水平比较,差异无统计学意义(P>0.05),治疗后,研究组血清激素水平较对照组显著升高,血清炎性因子水平较对照组显著下降,差异有统计学意义(P<0.05);研究组、对照组腹痛缓解时间分别为(5.13±1.08)d、(6.76±1.56)d,阴道止血时间分别为(4.07±1.01)d、(4.98±1.22)d,差异有统计学意义(P<0.05)。结论中西医结合治疗早期先兆流产,发挥中药、西药双重作用,改善临床症状,促进总体治疗效果,效果明确。
Objective To investigate the clinical efficacy of integrated traditional Chinese and Western medicine in the treatment of early threatened abortion.Methods A total of 88 patients with early threatened abortion who visited People’s Hospital of Gaomi from July 2021 to October 2022 were collected and divided into two groups using the random number table method,with 44 cases in each group.The two groups were treated with basic Western medicine therapy,and dydrogesterone tablets were given.The study group was supplemented with traditional Chinese medicine fetal protection prescription(codonopsis pilosula,astragalus membranaceus,prepared rehmannia root,semen cuscutae,salvia miltiorrhiza,taxilli herba,uncaria tomentosa,atractylodes macrocephala,scutellaria baicalensis,white peony,and licorice).Both groups were treated for 6 days as a course of treatment,with 2 courses of treatment in total.Efficacy standards were developed,serum hormone levels such as estradiol,chorionic gonadotropin,and progesterone in both groups of patients before and after treatment were detected,and inflammatory factors such as interleukin-2 and serum tumor necrosis factor-a were checked;Fetal development was monitored by Doppler ultrasound and the improvement of symptoms such as vaginal bleeding and abdominal pain in patients were recorded.Results The total effective rates of the study group and the control group were 93.18%and 79.54%,with 34 and 25 cases cured respectively,with statistical significance(P<0.05);Before treatment,there were no statistically significant differences in serum hormone levels and serum inflammatory factor levels between the two groups of patients(P>0.05).After treatment,the serum hormone levels in the study group were significantly higher than those in the control group,and the serum inflammatory factor levels decreased significantly compared to the control group,with statistically significant differences(P<0.05).The serum hormone levels in the study group increased significantly,while serum inflammatory factor levels
作者
王君君
何广云
刘欣荣
张屹
张建国
孙梅娟
王亮
WANG Junjun;HE Guangyun;LIU Xinrong;ZHANG Yi;ZHANG Jianguo;SUN Meijuan;WANG Liang(Obstetrics Department,People’s Hospital of Gaomi Affiliated to Weifang Medical University,Shandong,Gaomi 261500,China;Pharmacy Department,Traditional Chinese Medical Hospital of Huangdao District of Qingdao City,Shandong,Qingdao 266400,China;Medical Department,People’s Hospital of Gaomi Affiliated to Weifang Medical University,Shandong,Gaomi 261500,China)
出处
《中国医药科学》
2023年第15期103-106,157,共5页
China Medicine And Pharmacy
基金
山东省潍坊市中医药科研计划(2021-4-162,2021-4-144)
青岛大学医疗集团科研专项(2021-37号)。
关键词
早期先兆流产
地屈孕酮
炎性因子
雌激素
孕激素
中药组方
Early threatened abortion
Dydrogesterone
Inflammatory factor
Estrogen
Progesterone
Traditional Chinese medicine prescription
