摘要
目的探讨超声乳化白内障吸除术中眼表应用稀释的黏弹剂对泪膜稳定性的影响。方法前瞻性病例对照研究。收集滨州市中心医院2021年3月至2021年10月接受超声乳化白内障吸除人工晶状体植入术的干眼患者77例(90只眼)的临床资料,所有患者按随机数字表法分为临床试验组(A组)和对照组(B组),A组38例(45只眼),B组39例(45只眼)。A组术中眼表应用稀释的黏弹剂,B组术中眼表应用平衡盐溶液频繁滴眼。观察分析术前1 d及术后3、7、30 d行荧光素染色泪膜破裂时间(FBUT)、泪液分泌试验(SIt)、角膜荧光染色(CFS)检查;术前及术后7及30 d行结膜印记细胞学检查(CIC)。结果术前1 d两组患者FBUT、SIt、CFS、CIC差异均无统计学意义(均P>0.05)。术后30 d A组FBUT、SIt、CFS分别为(5.58±2.01)s、(6.62±2.83)mm及(6.20±1.97)分,与B组(3.44±1.71)s、(5.29±2.02)mm、(9.07±1.85)分相比差异均有统计学意义(均P<0.05)。术后7 d两组CIC结果异常细胞眼数比例增多,B组尤为明显(P<0.05),两组比较差异有统计学意义(P<0.05)。结论干眼患者超声乳化吸除术中眼表应用稀释的黏弹剂有利于恢复术后泪膜稳定性,对眼表微环境的修复起到促进作用。
Objective To evaluate the effect of application of diluted viscoelastics during phacoemulsification on tear film stability.Methods This was a prospective case-control study.The clinical data of 90 eyes of 77 patients with dry eye treated with phacoemulsification and intraocular lens implantation in Binzhou Central Hospital from Mar.2021 to Oct.2021 were collected,and they were divided into clinical trial group(group A)and control group(group B)based on random number table methods,with 45 eyes of 38 cases in group A and 45 eyes of 39 cases in group B.During surgery,diluted viscoelastics was applied in ocular surface for group A,while balanced salt solution was applied in ocular surface for group B.Fluorescein break up time(FBUT),Schirmer I test(SIt)and corneal fluorescein staining(CFS)were performed at 1 day before surgery and 3,7,30 days after surgery,and conjunctival impression cytology(CIC)was performed at 1 day before surgery and 7 and 30 days after surgery.Results There were no statistical differences in FBUT,SIt,CFS and CIC between the two groups at 1 day before surgery(all P>0.05).The FBUT,SIt,and CFS of group A at 30 days after surgery were(5.58±2.01)s,(6.62±2.83)mm,and(6.20±1.97)points,respectively,and those of group B were(3.44±1.71)s,(5.29±2.02)mm,and(9.07±1.85)points,respectively,which were all significantly different between the two groups(all P<0.05).The proportion of abnormal cells of both groups in CIC increased at 7 days after surgery,with a significant increase in group B(P<0.05).Conclusion The application of diluted viscoelastics in the ocular surface of dry eye patients during phacoemulsification is beneficial to the postoperative functional recovery of tear film and helps to repair the microenvironment of ocular surface.
作者
尹靓瑶
徐怡
李竑
张明明
李景翠
陈悦
Yin Liangyao;Xu Yi;Li Hong;Zhang Mingming;Li Jingcui;Chen Yue(Department of Ophthalmology,Binzhou Central Hospital Affiliated to Binzhou Medical College,Binzhou 251700,China;Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Henan Provincial Ophthalmic Hospital,Zhengzhou 450052,China)
出处
《中华眼外伤职业眼病杂志》
2023年第6期419-425,共7页
Chinese Journal of Ocular Trauma and Occupational Eye Disease
