摘要
【目的】观察滋肾育胎丸用于人工流产术后子宫内膜修复的临床疗效及安全性。【方法】将182例接受无痛人流术治疗的患者随机分为中药组62例、西药组59例和基础组61例。3组患者均予常规口服抗生素预防感染,中药组同时给予口服滋肾育胎丸治疗,西药组同时给予口服优思明治疗,基础组不予中西药治疗,疗程为21 d。比较3组患者术后阴道流血、腹痛、首次月经恢复、术后并发症及药物不良反应发生情况。【结果】(1)共179例患者完成试验,其中,中药组60例,西药组59例,基础组60例。(2)3组患者术后阴道流血时间、阴道流血量、腹痛视觉模拟量表(VAS)评分、腹痛持续时间比较,差异均有统计学意义(P<0.01)。组间两两比较(采用Bonferroni法调整α’为0.016),中药组能有效缩短患者术后阴道流血时间,减少阴道流血量,缓解患者腹痛不适,其疗效与西药组相当(P>0.016),均明显优于基础组(P<0.016)。(3)3组患者术后首次月经复潮时间、月经量比较,差异有统计学意义(P<0.05或P<0.01),而经期比较差异无统计学意义(P>0.05)。组间两两比较(采用Bonferroni法调整α’为0.016),中药组和西药组均能有效促进术后月经复潮,恢复月经量,与基础组比较,差异均有统计学意义(P<0.016),且均无延长经期之虞;同时,中药组在恢复术后月经量方面优于西药组(P<0.016)。(4)中药组、西药组和基础组患者的术后并发症发生率分别为10.00%(6/60)、15.25%(9/59)、10.00%(6/60),组间比较,差异无统计学意义(P>0.05)。(5)中药组、西药组和基础组的不良反应发生率分别为3.33%(2/60)、10.17%(6/59)、10.00%(6/60),组间比较,差异无统计学意义(P>0.05)。【结论】滋肾育胎丸可有效缩短人流术后阴道流血时间,减少阴道流血量,缓解患者腹痛不适;在促进人流术后子宫内膜修复方面疗效显著,可有效促进月经复潮,改善月经量,且不良反应少。
Objective To observe the clinical efficacy and safety of Zishen Yutai Pills for the restoration of endometrium after induced abortion.Methods A total of 182 patients who received painless induced abortion were randomly divided into Chinese medicine group(62 cases),western medicine group(59 cases)and basic treatment group(61 cases).Patients in the three groups were given oral use of conventional antibiotics to prevent infection,and additionally,the Chinese medicine group was also given oral use of Zishen Yutai Pills,while the western medicine group was given oral use of Yasmin.The course of treatment for the three groups covered 21 days.The incidences of postoperative vaginal bleeding,abdominal pain,first menstrual recovery,postoperative complications and adverse reactions of the drug were compared among the three groups.Results(1)A total of 179patients completed the trial,including 60 cases in the Chinese medicine group,59 cases in the western medicine group and 60 cases in the basic treatment group.(2)There were statistically significant differences in postoperative vaginal bleeding time,vaginal bleeding volume,abdominal pain visual analogue scale(VAS)scores and abdominal pain duration among the three groups after treatment(P<0.01).The intergroup comparison(α’being adjusted to 0.016 by Bonferroni method)showed that the Chinese medicine group had similar efficacy to western medicine group on effectively shortening the duration of postoperative vaginal bleeding,reducing the volume of vaginal bleeding and relieving abdominal pain and discomforts(P>0.016),and the efficacy of the two groups was significantly superior to that of the basic treatment group(P<0.016).(3)There were significant differences in the time of first menstrual recovery and menstrual volume among the three groups(P<0.05 or P<0.01),while there was no significant difference in menstrual period among the three groups(P>0.05).The intergroup comparison(α’being adjusted to 0.016 by Bonferroni method)showed that both Chinese medicine group and weste
作者
裴芳利
郑聪聪
邝梓君
陈晓鑫
曾诚
叶丽妮
PEI Fang-Li;ZHENG Cong-Cong;KUANG Zi-Jun;CHEN Xiao-Xin;ZENG Cheng;YE Li-Ni(The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The First Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;School of physical Education and Health,Guangdong Polytechnic Normal University,Guangzhou 510665 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2023年第1期81-88,共8页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家自然科学基金项目(编号:82074481)
罗元恺滋肾育胎丸中青年科研基金项目(编号:20190807)。
关键词
滋肾育胎丸
人工流产
子宫内膜修复
月经复潮
临床研究
Zishen Yutai Pills
induced abortion
restoration of endometrium
recovery of menstrual cycle
clinical research
