摘要
目的 研究尼可地尔治疗顽固性心绞痛患者的疗效及对心电图ST-T段的影响。方法 92例顽固性心绞痛患者,按照随机数字表法分为对照组和研究组,每组46例。对照组应用阿司匹林联合前列地尔常规治疗,研究组在对照组基础上应用尼可地尔治疗。比较两组患者治疗前后心电图ST-T段改变情况、血流动力学指标(全血粘度、血浆粘度、纤维蛋白原)、血清炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及治疗效果。结果 治疗后,研究组患者ST段下移、T波低平、T波倒置导联数分别为(2.77±0.12)、(1.82±0.24)、(1.91±0.24)个,均少于对照组的(3.52±0.68)、(2.19±0.14)、(2.19±0.73)个,差异具有统计学意义(P<0.05)。治疗后,研究组患者纤维蛋白原(3.18±0.49)g/L、血浆粘度(2.09±0.13)mPa·s、全血粘度(4.25±1.05)mPa·s均低于对照组的(3.85±0.58)g/L、(2.77±0.58)mPa·s、(5.03±1.94)mPa·s,差异具有统计学意义(P<0.05)。治疗后,研究组患者血清TNF-α、IL-6、CRP水平分别为(15.49±2.54)ng/L、(7.14±1.55)ng/L、(5.13±1.36)mg/L,均低于对照组的(24.39±5.47)ng/L、(13.84±3.25)ng/L、(7.82±1.26)mg/L,差异具有统计学意义(P<0.05)。研究组患者治疗总有效率为97.83%,高于对照组的80.43%,差异具有统计学意义(P<0.05)。结论 尼可地尔治疗顽固性心绞痛患者效果显著,能够减轻患者痛苦,同时改善心电图ST-T段,值得临床推广应用。
Objective To study the efficacy of nicorandil on patients with refractory angina pectoris and its influence on ST-T segment in electrocardiogram.Methods A total of 92 patients with refractory angina pectoris were divided into control group and study group according to random numerical table,with 46 cases in each group.The control group was treated with aspirin and alprostadil,and the study group was treated with nicorandil on the basis of the control group.Both groups were compared in terms of changes of ST-T segment in electrocardiogram,hemodynamic indexes(whole blood viscosity,plasma viscosity,fibrinogen),serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]before and after treatment,and therapeutic effects.Results After treatment,the number of leads of ST-segment depression,T-wave flattening,T-wave inversion were(2.77±0.12),(1.82±0.24)and(1.91±0.24)leads in the study group,which were less than those of(3.52±0.68),(2.19±0.14)and(2.19±0.73)leads in the control group,and the difference was statistically significant(P<0.05).After treatment,the study group had fibrinogen of(3.18±0.49)g/L,plasma viscosity of(2.09±0.13)mPa·s,and whole blood viscosity of(4.25±1.05)mPa·s,which were lower than those of(3.85±0.58)g/L,(2.77±0.58)mPa·s,and(5.03±1.94)mPa·s in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum TNF-α,IL-6 and CRP levels were(15.49±2.54)ng/L,(7.14±1.55)ng/L and(5.13±1.36)mg/L in the study group,which were lower than those of(24.39±5.47)ng/L,(13.84±3.25)ng/L and(7.82±1.26)mg/L in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment for patients in the study group was 97.83%,which was higher than that of 80.43%in the control group,and the difference was statistically significant(P<0.05).Conclusion Nicorandil has a significant effect on patients with refractory angina pectoris,and can reduce the pain of patients,and improve the
作者
张鑫
肖宁
ZHANG Xin;XIAO Ning(Electrocardiogram Room,Yanggu County People's Hospital,Liaocheng 252300,China)
出处
《中国现代药物应用》
2023年第15期7-10,共4页
Chinese Journal of Modern Drug Application
关键词
尼可地尔
顽固性心绞痛
心绞痛发作
心电图ST-T段
影响
Nicorandil
Refractory angina pectoris
Angina pectoris
ST-T segment in electrocardiogram
Influence
