摘要
结直肠癌是以高发病率和高死亡率为特征的消化系统恶性肿瘤,肝脏是结直肠癌最常见的转移部位。近年来结直肠癌肝转移的综合治疗虽得到广泛发展,但许多方案的使用对晚期患者预后仍不尽如人意,结直肠癌肝转移发生发展中的作用机制和针对性的治疗手段仍需进一步探索。肿瘤微环境已被证明在结直肠癌肝转移中发挥重要作用,而其中肿瘤微环境相关细胞的作用不可忽视,由于肿瘤微环境内的相关细胞在遗传上是稳定的,因此可能成为一种有吸引力的治疗靶点。有关肿瘤微环境相关细胞与结直肠癌肝转移关系的相关报道日益增多,现就近年来肿瘤微环境中的细胞成分与结直肠癌肝转移的研究进展作一综述。
Colorectal cancer is a malignant tumor of the digestive system characterized by high morbidity and mortality.Liver is the most common metastatic sites of colorectal cancer.In recent years,the comprehensive treatment of colorectal cancer liver metastasis(CRLM)has been widely developed,but the prognosis of advanced patients is still unsatisfactory.The mechanism of action and targeted treatment of CRLM still need to be further explored.Tumor microenvironment(TME)has been proved to play an important role in CRLM,and the role of TME-related cells cannot be ignored.As the related cells in TME are genetically stable,they may become a kind of attractive therapeutic target.There are increasing reports on the relationship between TME related cells and CRLM.This article reviewed the research progress of cell components in TME and CRLM in recent years.
作者
陈舒
张楠
荣康
孙维义
郅强
杨世发
沙俊生
高楠
CHEN Shu;ZHANG Nan;RONG Kang;SUN Weiyi;ZHI Qiang;YANG Shifa;SHA Junsheng;GAO Nan(Henan University of Chinese Medicine,Zhengzhou 450046;Minimally Invasive Endoscopic Surgery,the First Affiliated Hospitalof Henan University of Traditional Chinese Medicine;Department of Gastroenterology,the Fifth Affiliated Hospital of ZhengzhouUniversity,China)
出处
《胃肠病学和肝病学杂志》
CAS
2023年第8期933-940,共8页
Chinese Journal of Gastroenterology and Hepatology
基金
河南省卫生健康委国家中医临床研究基地科研专项(2021JDZY026)。
关键词
结直肠癌肝转移
肿瘤微环境
综述
Colorectal cancer liver metastasis
Tumor microenvironment
Reviews
