摘要
髓源性抑制细胞(MDSC)是一群具有免疫抑制作用的未成熟骨髓细胞,其大量存在于肿瘤患者体内,诱导肿瘤细胞逃脱免疫细胞的杀伤,促进肿瘤的发生、进展、转移。近年来,其在肝癌微环境中的作用受到广泛关注,但其在肝癌微环境中募集、分化的相关机制仍未有清晰的阐述。主要总结了肝癌微环境中的肿瘤细胞和肿瘤基质细胞如肝星状细胞、肿瘤相关成纤维细胞、肿瘤相关内皮细胞等对MDSC分化、募集的作用机制,提出靶向MDSC作为辅助疗法以增强肝癌免疫治疗的潜在价值。
Myeloid-derived suppressor cells(MDSCs)are a group of immature bone marrow cells with an immunosuppressive effect,and they are abundant in tumor patients and can induce tumor cells to escape the killing of immune cells and thus promote the development,progression,and metastasis of tumor.In recent years,its role in hepatocellular carcinoma microenvironment has attracted more and more attention,but the mechanisms of its recruitment and differentiation in hepatocellular carcinoma microenvironment have not been clearly elucidated.This article mainly summarizes the mechanism of action of tumor cells and tumor stromal cells in hepatocellular carcinoma microenvironment(such as hepatic stellate cells,tumor-associated fibroblasts,and tumor-associated endothelial cells)in the recruitment and differentiation of MDSCs,and it is proposed to target MDSCs as an adjuvant therapy to enhance the potential value of immunotherapy for liver cancer.
作者
李雪艳
王昌俊
LI Xueyan;WANG Changjun(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510000,China;Department of TCM,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangdong Institute of Geriatrics,Guangzhou 510000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2021年第6期1473-1476,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金(81774261)。
关键词
癌
肝细胞
肿瘤微环境
髓源性抑制细胞
肝星状细胞
Carcinoma,Hepatocellular
Tumor Microenvironment
Myeloid-Derived Suppressor Cells
Hepatic Stellate Cells
