摘要
目的 探讨采取拉贝洛尔辅助硫酸镁治疗妊娠高血压综合征(简称妊高症)的疗效与安全性。方法 选取2021年6月—2022年6月济南市莱芜人民医院妇产科收治的82例妊高症患者,根据治疗方式分为观察组和参考组,各41例。参考组采取常规治疗方式,观察组则在此基础上联合拉贝洛尔进行治疗。分析并对比两组患者血压控制效果、生理检测指标水平、并发症情况及不良母婴结局。结果 治疗后,两组患者的收缩压、舒张压均明显改善,且观察组血压控制情况优于参考组,差异有统计学意义(P<0.05)。观察组患者的24 h尿蛋白(1.26±0.33)g/d、C反应蛋白(0.38±0.11)g/L、血清同型半胱氨酸(12.45±2.11)μmol/L均低于参考组,差异有统计学意义(P<0.05)。观察组并发症发生率为4.88%,低于参考组,差异有统计学意义(χ^(2)=7.405,P<0.05)。观察组的不良母婴结局发生率为4.88%,低于参考组,差异有统计学意义(χ^(2)=8.613,P<0.05)。结论 在妊高症的治疗过程中应用拉贝洛尔辅助硫酸镁可以有效改善患者的临床症状和并发症情况,降低24 h尿蛋白、C反应蛋白及血清中同型半胱氨酸含量,同时能降低并发症发生率及不良母婴结局发生率,更为安全有效。
Objective To explore the efficacy and safety of Labetalol combined with magnesium sulfate in the treat‐ment of pregnancy induced hypertension syndrome(PIH).Methods 82 patients with pregnancy induced hypertension admitted to the Obstetrics and Gynecology Department of Laiwu People´s Hospital in Jinan from June 2021 to June 2022 were selected and divided into an observation group and a reference group based on treatment methods,with 41 patients in each group.The reference group was treated with conventional treatment,while the observation group was treated with Labetalol on this basis.Analyzed and compared the blood pressure control effect,physiological detection index levels,complications,and adverse maternal and infant outcomes between two groups of patients.Results After treatment,the systolic and diastolic blood pressure of both groups of patients improved significantly,and the blood pressure control in the observation group was better than that in the reference group,and the difference was statisti‐cally significant(P<0.05).The 24-hour urinary protein(1.26±0.33)g/d,C-reactive protein(0.38±0.11)g/L,and se‐rum homocysteine(12.45±2.11)μmol/L in the observation group were lower than those in the reference group,and the difference was statistically significant(P<0.05).The incidence of complications in the observation group was 4.88%,lower than the reference group,and the difference was statistically significant(χ^(2)=7.405,P<0.05).The incidence of ad‐verse maternal and infant outcomes in the observation group was 4.88%,lower than the reference group,and the differ‐ence was statistically significant(χ^(2)=8.613,P<0.05).Conclusion In the treatment of pregnancy induced hypertension,the application of Labetalol in combination with magnesium sulfate can effectively improve the clinical symptoms and complications of patients,reduce the content of 24-hour urinary protein,C-reactive protein and serum homocysteine,and reduce the incidence of complications and the incidence of adverse maternal and infant out
作者
苏丽丽
谢凤霞
SU Lili;XIE Fengxia(Department of Obstetrics and Gynecology,Laiwu People's Hospital,Jinan,Shandong Province,271100 China)
出处
《系统医学》
2023年第9期163-166,共4页
Systems Medicine
关键词
拉贝洛尔
硫酸镁
妊娠高血压
安全性
Labetalol
Magnesium sulfate
Hypertension in pregnancy
Safety
