摘要
目的探究纤维支气管镜肺泡灌洗联合雾化吸入乙酰半胱氨酸治疗儿童大叶性肺炎后塑型性支气管炎的临床效果。方法纳入2019年10月至2022年10月驻马店市中心医院86例大叶性肺炎后塑型性支气管炎患儿为研究对象,采用随机数字表法分为两组,各43例。两组均接受常规治疗,对照组接受纤维支气管镜肺泡灌洗治疗,在此基础上,观察组接受雾化吸入乙酰半胱氨酸治疗。比较两组疗效,观察临床症状消失时间,比较治疗前、治疗2周时患儿炎症因子水平[肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-6(IL-6)]及肺通气功能指标[第1秒用力呼气容积占预计值百分比(FEV_(1)%pred)、最大呼气流速(PEF)、1秒率(FEV_(1)/FVC)]。统计治疗期间两组不良反应发生情况。结果治疗2周,与对照组比较,观察组治疗总有效率高(P<0.05)。与对照组比较,观察组发热、气促、咳嗽咳痰、湿啰音症状消失时间均短(P<0.05)。治疗2周,两组血清TNF-α、IFN-γ、IL-6均较治疗前降低,且观察组低于对照组(P<0.05)。治疗2周,两组FEV_(1)%pred、PEF、FEV_(1)/FVC水平均较治疗前提高,且观察组高于对照组(P<0.05)。结论纤维支气管镜肺泡灌洗联合雾化吸入乙酰半胱氨酸治疗儿童大叶性肺炎后塑型性支气管炎的效果确切,可缓解患儿临床症状,减轻炎症反应,促进肺通气功能恢复。
Objective To investigate the clinical effect of fiber bronchoscope alveolar lavage combined with aerosol inhalation of acetylcysteine on plastic bronchitis after lobar pneumonia in children.Methods A total of 86 children with plastic bronchitis after lobar pneumonia in Zhumadian Central Hospital from October 2019 to October 2022 were selected as the study subjects.According to random number table,they were divided into two groups,with 43 cases respectively.Conventional therapy was used in both groups,fiber bronchoscope alveolar lavage was used in control group,and atomized inhalation of acetylcysteine on the basis of the control group was used in observation group,and the effect of treatment was compared.The disappearance time of clinical symptoms was observed.The levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-6(IL-6)]and pulmonary ventilation function indexes[the forced expiratory volume in one second/predicted value ratio(FEV_(1)%pred),peak expiratory flow(PEF),one second rate(FEV_(1)/FVC)]were compared before treatment and 2 weeks after treatment.The incidence of adverse reactions in the two groups during treatment was counted.Results Compared with the control group,after 2 weeks of treatment,the total effective rate of the observation group was higher(P<0.05).The disappearance time of fever,shortness of breath,cough,expectoration and wet rale symptoms in the observation group were shorter in comparison with the control group(P<0.05).After 2 weeks of treatment,compared with before treatment,serum TNF-α,IFN-γand IL-6 in both groups were lower,and the observation group were lower than the control group(P<0.05).After 2 weeks of treatment,compared with before treatment,levels of FEV_(1)%pred,PEF,FEV_(1)/FVC in both groups were higher,and the observation group were higher than the control group(P<0.05).Conclusion Fiber bronchoscope alveolar lavage combined with aerosol inhalation of acetylcysteine is effective in the treatment of plastic bronchitis after lobar pn
作者
陈茜
张雷
高清丽
付亮
CHEN Xi;ZHANG Lei;GAO Qingli;FU Liang(Department of Pediatrics,Zhumadian Central Hospital,Zhumadian 463000,China)
出处
《河南医学研究》
CAS
2023年第15期2801-2804,共4页
Henan Medical Research
