摘要
冷冻电镜技术已成为生命科学领域研究结构和功能的重要技术手段,冷冻电镜平台的建设给高校和科研院所的学科发展带来新的突破口。现以浙江大学冷冻电镜中心的建设与运行为例,阐述了冷冻电镜平台的仪器架构和3+X创新运行模式,剖析了运行中存在的问题,提出了相应对策,旨在探索冷冻电镜平台高效、良性的运行机制和管理模式。
Cryo-electron microscopy is one of the most important technologies for structural and functional research in life science.The construction of cry-electron microscopy facility brings a new breakthrough to the development of universities and institutes.Based on the construction and operations of Center of Cryo-Electron Microscopy,Zhejiang University,this paper expounds the architecture of instruments and 3+X operation mode,analyzes the problems existing in the operation,and puts forward corresponding countermeasures,aiming to explore the efficient and benign operation mechanism and management mode of the cryo-electron microscope facility.
作者
吴航军
韩琴
肖桂凤
林赵肖楠
戎叶
WU Hangjun;HAN Qin;XIAO Guifeng;LIN Zhaoxiaonan;RONG Ye(School of Medicine,Zhejiang University,Hangzhou 310058,China;School of Basic Medical Sciences,Hangzhou Normal University,Hangzhou 311121,China)
出处
《实验室研究与探索》
CAS
北大核心
2023年第5期304-309,共6页
Research and Exploration In Laboratory
基金
浙江大学实验技术研究项目重点专项(SZD202102)
浙江省教育厅一般科研项目(Y202147260)。
关键词
冷冻电镜平台
平台建设与管理
运行模式
cryo-electron microscopy facility
facility construction and management
operation mode
