摘要
【目的】探讨心脉隆注射液联合利巴韦林治疗病毒性心肌炎伴心功能不全患者的临床疗效。【方法】选取2019年9月至2021年11月本院收治的106例由柯萨奇病毒感染导致的病毒性心肌炎伴心功能不全患者,根据治疗方法的不同将其分为观察组和对照组,每组53例。对照组采用利巴韦林治疗,观察组在对照组的基础上给予心脉隆注射液治疗。比较两组临床疗效、超声心功能指标[左心室射血分数(LVEF)、左心室短轴缩短率(FS)、左心室舒张末期内径(LVEDD)、心脏指数(CI)]及血清脑钠肽(BNP)、超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽(GSH)、肌酸肌酶(CK)、肌酸激酶同工酶(CK-MB)水平,比较两组不良反应发生率。【结果】观察组临床总有效率为96.23%(51/53),高于对照组的81.13%(43/53),差异有统计学意义(P<0.05)。治疗后,两组LVEF、FS、CI高于治疗前,观察组高于对照组(P<0.05);两组LVEDD低于治疗前,观察组低于对照组(P<0.05);两组血清BNP、CK-MB、LDH、CK水平低于治疗前,观察组低于对照组(P<0.05);两组血清MDA水平低于治疗前,观察组低于对照组(P<0.05);两组血清SOD、GSH水平高于治疗前,观察组高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】心脉隆注射液联合利巴韦林治疗病毒性心肌炎伴心功能不全的临床疗效较佳,可改善患者心功能,改善机体氧化应激状态。
【Objective】To investigate the clinical efficacy of Xinmailong injection combined with Ribavirin in the treatment of viral Myocarditis with cardiac insufficiency.【Methods】From September 2019 to November 2021,106 patients with viral myocarditis and cardiac insufficiency caused by coxsackie virus infection in our hospital were selected and divided into an observation group and a control group according to the different treatment methods,with 53 cases in each group.The control group was treated with Ribavirin,and the observation group was treated with Xinmailong injection on the basis of the control group.The clinical efficacy,ultrasonic cardiac function indexes[left ventricular Ejection fraction(LVEF),left ventricular short axis shortening rate(FS),left ventricular end diastolic diameter(LVEDD),cardiac index(CI)],serum brain natriuretic peptide(BNP),Superoxide dismutase(SOD),Malondialdehyde(MDA),and glutathione(GSH)levels were compared between the two groups.【Results】The total clinical effective rate of the observation group was 96.23%(51/53),which was higher than 81.13%(43/53)of the control group,with a statistically significant difference(P<0.05).After treatment,LVEF,FS,and CI in both groups were higher than before treatment,while the observation group was higher than the control group(P<0.05);The LVEDD of the two groups was lower than before treatment,while the observation group was lower than the control group(P<0.05);The levels of serum BNP,CK-MB,LDH,and CK in the two groups were lower than before treatment,while those in the observation group were lower than those in the control group(P<0.05);The serum MDA levels in both groups were lower than before treatment,while those in the observation group were lower than those in the control group(P<0.05);The serum SOD and GSH levels in both groups were higher than before treatment,while the observation group was higher than the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the tw
作者
王文静
WANG Wen-jing(Hospital of Kaifeng,Kaifeng Henan 475000)
出处
《医学临床研究》
CAS
2023年第7期1036-1038,1042,共4页
Journal of Clinical Research
