尺胫针加电针联合骨痹汤熏蒸对腰椎间盘突出症患者下肢感觉障碍改善、神经传导速度和血清TLR4信号通路的影响被引量：4

Effects of Ulnar-Tibial Acupuncture Plus EA Combined with Gubi Decoction Fumigation on Improvements of Lower Extremity Sensory Disturbance,Nerve Conduction Velocity and Serum TLR4 Signaling Pathway in Treating LDH

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摘要目的:探讨尺胫针加电针联合骨痹汤熏蒸对腰椎间盘突出症患者的下肢感觉障碍改善、神经传导速度和血清TLR4信号通路的影响。方法:将112例腰椎间盘突出症患者作为本研究对象,病例收集时间为2021年6月—2022年1月,将112例研究对象分为对照组和试验组,对照组采取骨痹汤熏蒸治疗,试验组采取骨痹汤熏蒸联合尺胫针加电针治疗。两组均治疗8周。对比两组患者疗效情况、VAS麻木评分、改良MRC肌力分级评分、感觉功能评分、直腿抬高角度、腓总神经和胫总神经传导速度以及Toll样3受体4(TLR4)和核因子-κB(NF-κB)表达水平。结果:试验组治疗总有效率94.64%(53/56),比对照组的82.14%(46/56)显著更高,差异具有统计学意义(P<0.05);治疗结束后对照组和试验组VAS评分与治疗前比较均降低,且试验组VAS评分比对照组显著更低,差异具有统计学意义(P<0.05);治疗结束后两组浅感觉、深感觉与复合感觉评分与治疗前比较均升高,且试验组浅感觉、深感觉与复合感觉评分比对照组显著更高,差异具有统计学意义(P<0.05);治疗结束后两组直腿抬高角度与治疗前比较均升高,且试验组直腿抬高角度比对照组显著更高,差异具有统计学意义(P<0.05);对照组和试验组改良MRC评分与治疗前比较均升高,且试验组改良MRC评分比对照组显著更高,差异具有统计学意义(P<0.05);治疗结束后对照组和试验组腓总神经传导速度、胫总神经传导速度和F波出现率与治疗前比较均升高,且试验组腓总神经传导速度、胫总神经传导速度和F波出现率比对照组显著更高,差异具有统计学意义(P<0.05);治疗结束后对照组和试验组TLR4 mRNA和NF-κB mRNA表达水平与治疗前比较均降低,且试验组TLR4 mRNA和NF-κB mRNA表达水平比对照组显著降低,差异具有统计学意义(P<0.05)。结论:尺胫针加电针联合骨痹汤熏蒸对腰椎间盘突出症患者下肢感觉障碍 Objective:To investigate the effects of ulnar-tibial acupuncture plus electro-acupuncture(EA)combined with Gubi Decoction fumigation on the improvements of lower limb sensory disturbance,nerve conduction velocity and serum TLR4 signaling pathway in patients with lumbar disc herniation(LDH).Methods:112 patients with LDH were selected as the research subjects of this study.The case collection time was from June 2021 to January 2022.The 112 research subjects were divided into the control group and the study group.The control group was treated with Gubi Decoction fumigation;on which basis,the study group was also treated with ulnar-tibial acupuncture plus EA.Both groups were treated for 8 weeks.Curative effect,VAS numbness score,modified MRC muscle strength grading score,sensory function score,straight leg raise angle,conduction velocity of common peroneal nerve and common tibial nerve,and expressions of Toll-like 3 receptor 4(TLR4)and nuclear factor-κB(NF-κB)were compared between the two groups.Results:The total effective rate of the study group was 94.64%(53/56),which was significantly higher than 82.14%(46/56)of the control group(P<0.05).The VAS score was decreased after the treatment compared with that before the treatment in the two groups,and the VAS score was lower in the study group than that in the control group after the treatment(P<0.05).The scores of superficial sensation,deep sensation and composite sensation were all increased after the treatment compared with those before the treatment in the two groups,and the increases in the study group were more significant than those in the control group(P<0.05).The straight leg raising angle was increased after the treatment compared with that before the treatment in the two groups,and the straight leg raising angle of the study group was significantly higher than that of the control group after the treatment(P<0.05).The modified MRC score was higher after the treatment than that before the treatment in the two groups,in which the study group was higher than th

作者张立颖唐懿张健王向向柴雪姣王秀粉郭会敏 ZHANG Liying;TANG Yi;ZHANG Jian;WANG Xiangxiang;CHAI Xuejiao;WANG Xiufen;GUO Huimin(Shijiazhuang Second Hospital,Shijiazhuang 050001,China;Shijiazhuang Ping an Hospital,Shijiazhuang 050025,China;Shijiazhuang Third Hospital,Shijiazhuang 050011,China)

机构地区石家庄市第二医院石家庄平安医院石家庄市第三医院

出处《针灸临床杂志》 2023年第7期25-30,共6页 Journal of Clinical Acupuncture and Moxibustion

基金河北省中医药科研计划,编号:2020277。

关键词腰椎间盘突出症骨痹汤中药熏蒸尺胫针电针感觉障碍神经传导 Toll样3受体4 Lumbar disc herniation Gubi Decoction Chinese herbal fumigation Ulnar-tibial acupuncture Electro-acupuncture Sensory disturbance Nerve conduction TLR4

分类号 R246.2 [医药卫生—针灸推拿学]