摘要
目的:分析吉西他滨—洛铂静脉滴注对局部晚期宫颈癌患者血清肿瘤标志物、免疫介质及炎症介质水平的影响。方法:选取2017年3月—2019年4月佳木斯市肿瘤结核医院收治的90例晚期宫颈癌患者作为研究对象,采用随机数表法分为观察组与对照组,每组各45例。对照组采用吉西他滨—顺铂静脉滴注化疗2个疗程(3周为1个疗程),观察组采用吉西他滨—洛铂静脉滴注化疗2个疗程(3周为1个疗程),比较两组患者化疗前后血清肿瘤标志物、免疫介质和炎症介质的水平。结果:治疗后,两组患者癌胚抗原(CEA)、神经元特异性烯醇酶(NSE)、细胞角蛋白21-1片段(CYFRA21-1)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)水平均显著低于治疗前,且观察组CEA、NSE、CYFRA21-1、CA125、CA19-9水平均低于对照组,差异有统计学意义(t=20.980、7.938、17.322、9.260、15.005,P<0.05)。治疗后,两组患者辅助性T细胞1、2、17(Th1、Th2、Th17)水平均显著低于治疗前,且观察组Th1、Th2、Th17水平均低于对照组,差异有统计学意义(t=18.381、12.756、7.387,P<0.05)。治疗后,两组患者肿瘤坏死因子-α(TNF-α)、转化生长因子β(TGF-β)水平均显著低于治疗前,白细胞介素-10(IL-10)水平显著高于治疗前,且观察组TNF-α、TGF-β水平均低于对照组,IL-10水平高于对照组,差异有统计学意义(t=4.586、2.827、29.504,P<0.05)。结论:相较于吉西他滨—顺铂静脉滴注,吉西他滨—洛铂静脉滴注应用于局部晚期宫颈癌患者中可以有效降低患者血清肿瘤标志物、免疫介质水平,同时还可以降低患者的炎症介质水平。
Objective:To analyze the effects of gemcitabine-lopressor intravenous drip on the levels of serum tumor markers,immune mediators,and inflammatory mediators in patients with locally advanced cervical cancer.Methods:90 cases of advanced cervical cancer patients admitted to the hospital from March 2017 to April 2019 were selected as the study subjects and were divided into observation group and control group using the random number table method,with 45 cases in each group.The control group was treated with 2 courses(3 weeks as 1 course)of gemcitabine-cisplatin intravenous chemotherapy and the observation group was treated with 2 courses(3 weeks as 1 course)of gemcitabine-lopressor intravenous chemotherapy.The differences in the levels of serum tumor markers,immune mediators and inflammatory mediators before and after chemotherapy were compared between the two groups.Results:After treatment,the levels of CEA,NSE,CYFRA21-1,CA125,and CA19-9 were significantly lower in both groups than before treatment,and the levels of CEA,NSE,CYFRA21-1,CA125,and CA19-9 were lower in the observation group than in the control group,and the differences were statistically significant(t=20.980,7.938,17.322,9.260,15.005,P<0.05).After treatment,the levels of Th1,Th2 and Th17 were significantly lower in both groups than before treatment,and the levels of Th1,Th2 and Th17 in the observation group were lower than those in the control group,with statistically significant differences(t=18.381,12.756,7.387,P<0.05).After treatment,TNF-αand TGF-βlevels were significantly lower and IL-10 levels were significantly higher in both groups than before treatment,and TNF-αand TGF-βlevels were lower and IL-10 levels were higher in the observation group than in the control group,with statistically significant differences(t=4.586,2.827,29.504,P<0.05).Conclusion:Compared with gemcitabine-cisplatin intravenous drip,gemcitabine-lopressor intravenous drip in patients with locally advanced cervical cancer can effectively reduce the level of serum tumor markers
作者
芦明月
Lu Mingyue(DepartmentⅠof Oncology,Jiamusi Cancer and Tuberculosis Hospital,Jiamusi,Heilongjiang,154007,China)
出处
《黑龙江医学》
2023年第16期1948-1950,共3页
Heilongjiang Medical Journal
关键词
吉西他滨
洛铂
单纯放疗
宫颈癌
免疫介质
炎症介质
Gemcitabine
Los platinum
Simple radiotherapy
Cervical cancer
Immune mediator
Inflammatory mediators
