摘要
目的探讨宫颈锥切术治疗宫颈上皮内瘤变(CIN)的效果及对术后复发情况的影响。方法选取2018年7月至2020年7月收治的90例CIN患者为研究对象,根据手术治疗方式不同将其分为对照组和试验组,各45例。对照组接受宫颈环形电切术(LEEP)治疗,试验组接受宫颈锥切术治疗。比较两组的治疗效果。结果试验组的手术时间长于对照组,术中出血量多于对照组,住院时间短于对照组,治疗费用低于对照组,差异具有统计学意义(P<0.05)。试验组的标本切缘阳性率、复发率低于对照组,治愈率高于对照组,差异具有统计学意义(P<0.05)。术后3 d,试验组的生长分化因子-15(GDF-15)、CXC亚家族趋化因子13(CXCL13)及白细胞介素-6(IL-6)水平低于对照组,差异具有统计学意义(P<0.05)。试验组的不良事件总发生率为4.44%,低于对照组的26.67%,差异具有统计学意义(P<0.05)。结论宫颈锥切术治疗CIN效果较好,能彻底清除病灶,减轻术后炎症反应,降低复发率及不良事件发生率,值得推广。
Objective To explore the effect of cervical conization in the treatment of cervical intraepithelial neoplasia(CIN)and its influence on postoperative recurrence status.Methods A total of 90 patients with CIN admitted from July 2018 to July 2020 were selected as the research objects.According to different surgical treatment methods,the patients were divided into control group and experimental group,with 45 cases in each group.The control group was treated with loop electrosurgical excision procedure(LEEP),and the experimental group was treated with cervical conization.The therapeutic effects of the two groups were compared.Results The operation time of the experimental group was longer than that of the control group,the intraoperative blood loss was more than that of the control group,the hospitalization time was shorter than that of the control group,and the treatment cost was lower than that of the control group,the differences were statistically significant(P<0.05).The positive rate of specimen margin and recurrence rate in the experimental group were lower than those in the control group,and the cure rate was higher than that in the control group,the differences were statistically significant(P<0.05).At 3 d after operation,the levels of growth differentiation factor-15(GDF-15),CXC subfamily chemokine 13(CXCL13)and interleukin-6(IL-6)in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse events in the experimental group was 4.44%,which was lower than 26.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion Cervical conization is effective in the treatment of CIN.It can completely remove the lesion,reduce the postoperative inflammatory response,reduce the recurrence rate and the incidence of adverse events.It is worth promoting.
作者
宋爱英
杨玲玲
魏建勋
SONG Aiying;YANG Lingling;WEI Jianxun(Gynecology and Obstetrics Department,Ansai District Maternal and Child Health Hospital,Yan'an 717400;Gynecology and Obstetrics Department,Ansai District People's Hospital,Yan'an 717400;No.1 Obstetrics Department,Yan'an University Affiliated Hospital,Yan'an 716000,China)
出处
《临床医学研究与实践》
2023年第23期57-60,共4页
Clinical Research and Practice
关键词
宫颈上皮内瘤变
宫颈锥切术
宫颈环形电切术
复发情况
cervical intraepithelial neoplasia
cervical conization
loop electrosurgical excision procedure
recurrence status
