摘要
目的探析宫颈上皮内瘤变(CIN)采用LEEP刀宫颈锥切术与术前术后联合应用重组α-2b干扰素栓治疗的临床效果。方法选择2015年1月—2018年1月该院接收的CIN患者260例,遵从双盲法分组标准均分为参照组、试验组,各130例,两组均采取LEEP刀宫颈锥切术治疗,参照组术后给予重组α-2b干扰素栓,试验组术前术后均应用重组α-2b干扰素栓。比较两组治疗效果、手术指标、免疫功能及复发率。结果试验组总疗效为96.15%,明显高于参照组的81.54%,复发率0.77%低于参照组33.85%,差异有统计学意义(χ~2=14.011 0,P=0.000 2;χ~2=49.688 9,P=0.000 0);参照组出血量(25.28±3.27)mL及愈合时间(5.72±1.83)d均大于试验组(4.49±1.71)mL与(4.11±1.52)d,差异有统计学意义(t=64.237 0,P=0.000 0;t=7.716 4,P=0.000 0);两组免疫功能指标诸如IgM(0.91±0.49)%vs (0.69±0.41)%对比差异有统计学意义(t=3.926 1,P=0.000 0)。结论 CIN采用LEEP刀宫颈锥切术结合重组α-2b干扰素栓术前术后使用效果显著,可调节免疫功能,降低复发率,值得采纳。
Objective To investigate the clinical effect of cervical intraepithelial neoplasia(CIN)with LEEP knife conization and preoperative and postoperative combined with recombinant α-2b interferon suppository.Methods A total of 260 patients with CIN received from January 2015 to January 2018 were enrolled.The double-blind grouping criteria were divided into reference group and experimental group,130 cases each.Both groups underwent LEEP scalpel conization.For the treatment,the reference group was given recombinant α-2b interferon suppository,and the experimental group was treated with recombinant α-2b interferon suppository before and after operation.The treatment effects,surgical indexes,immune function and recurrence rate were compared between the two groups.Results The total efficacy of the experimental group was 96.15%,which was significantly higher than 81.54% of the reference group.The recurrence rate was 0.77% lower than that of the reference group 33.85%,which the difference was statistically significant(χ^2=14.011 0,P=0.000 2;χ^2=49.688 9,P=0.000 0).The reference group bleeding volume(25.28±3.27)mL and healing time(5.72±1.83)d were greater than the test group(4.49±1.71)mL and(4.11±1.52)d,forming the difference was statistical significance(t=64.237 0,P=0.000 0;t=7.716 4,P=0.000 0);two groups of immune function indicators such as IgM(0.91±0.49)% vs(0.69±0.41)%,there was statistical significance(t=3.926 1,P=0.000 0).Conclusion CIN using LEEP knife cervical conization combined with recombinant α-2b interferon suppository has a significant effect before and after surgery.It can regulate immune function and reduce recurrence rate.It is worthy of adoption.
作者
曲艳妮
曲奕颖
王莉
QU Yan-ni;QU Yi-ying;WANG Li(Maternal and Child Health Hospital of Huancui District,Weihai,Shandong Province,264200 China;Rongcheng City Hospital of TCM,Weihai,Shandong Province,264300 China)
出处
《系统医学》
2019年第2期99-101,共3页
Systems Medicine
关键词
宫颈上皮内瘤变
复发率
重组α-2b干扰素栓
LEEP刀宫颈锥切术
Cervical intraepithelial neoplasia
Recurrence rate
Recombinant α-2b interferon suppository
LEEP knife cervical conization
