摘要
目的 分析晚期子宫内膜癌(EC)患者临床病理特征及预后影响因素。方法 选择165例晚期EC患者,收集患者的临床病理资料,依据患者术后3年总体生存(OS)情况分为死亡组、生存组。分析EC患者临床病理特征,采用Logistic回归方法分析患者预后影响因素。结果 165例晚期EC患者平均年龄(54.98±6.09)岁;FIGO分期Ⅲ期94例,Ⅳ期71例;组织学分级低分化67例,高、中分化98例;肌层浸润≥1/2 70例,<1/2 95例;PR表达阳性115例,阴性50例;雌激素受体(ER)表达阳性93例,阴性72例;死亡组非子宫内膜样癌、组织学分级低分化、肌层浸润≥1/2、孕激素受体(PR)表达阴性、术后未辅助治疗患者占比高于生存组,差异有统计学意义(P<0.05);Logistic回归分析显示,病理类型、组织学分级、肌层浸润、PR表达、术后未辅助治疗是晚期EC患者预后的影响因素(P<0.05且OR≥1)。结论 晚期EC患者预后影响因素主要包括病理类型、组织学分级、肌层浸润、PR表达、术后未辅助治疗等,分析患者临床病理特征及预后影响因素可为病情评估及生存结局预测提供指导。
Objective To analyze the clinicopathological features and prognostic factors in patients with advanced endometrial cancer(EC).Methods 165 patients with advanced EC were selected.Data on patient demographic,clinicopathological and postoperative adjuvant treatment and survival information were collected,and divided into death and survival groups according to their overall survival(OS) at 3 years after surgery.Clinclinicopathological features of EC patients were analyzed and prognostic factors were analyzed by Logistic regression.Results The mean age of 165 patients with advanced EC was(54.98±6.09) year;The FIGO staging occurred 94 cases of stage Ⅲ,71 cases of stage Ⅳ;Histological grade showed low differentiation in 67 cases,High and moderate differentiation in 98 cases;muscle layer infiltration ≥ 1/2 was 70 cases,1/2 was 95 cases;The PR expression was positive in 115 cases,Negative in 50 cases;Estrogen receptor(ER) expression was positive in 93 cases,Negative in 72 cases;The proportion of patients with non-endometrioid carcinoma,low histological grade differentiation,myometrial infiltration ≥ 1/2,negative expression of progesterone receptor(PR) expression,and unadjuvant treatment was higher than that in the survival group,The difference was statistical significant(P<0.05);The logistic regression analysis showed that,Pathological type,histological grade,myometrial infiltration,PR expression,and postoperative unadjuvant treatment were the factors of prognostic influence in patients with advanced EC(P<0.05 and OR 1).Conclusion Prognostic influencing factors in patients with advanced EC mainly include pathological type,histological grade,myometry infiltration,PR expression,postoperative unadjuvant therapy,etc.Analysis of patient clinicopathological characteristics and prognostic influencing factors can provide guidance for condition assessment and survival outcome prediction.
作者
翟梦姣
孙丽莎
张娟
ZHAI Mengjiao;SUN Lisa;ZHANG Juan(Jiaozuo Second People's Hospital,Jiaozuo,454000)
出处
《实用癌症杂志》
2023年第8期1361-1364,共4页
The Practical Journal of Cancer
关键词
子宫内膜癌
晚期
临床病理特征
预后
影响因素
Endometrial cancer
Advanced stage
Clinicopathological features
Prognosis
Influencing factors
