摘要
目的:探讨外周动脉支架术后再狭窄与炎性因子的关系及其对准分子激光联合药涂球囊治疗效果。方法:分析2019年8月至2022年8月阜外华中心血管病医院(河南省人民医院心脏中心)血管外科及河南省人民医院血管外科收治的30例外周动脉支架术后再狭窄患者的临床资料,作为研究组,同时选取30例未发生再狭窄患者作为对照组。收集两组患者外周血,采用酶联免疫吸附检测法(ELISA)检测血清炎性因子超敏C反应蛋白(hs-CRP)和白细胞介素(IL-6)水平。采用Logistic回归方程相关性分析外周血hs-CRP、IL-6等炎性因子水平与外周动脉支架术后再狭窄的相关性。30例外周动脉支架术后再狭窄患者采用准分子激光联合药涂球囊进行治疗,评价患者治疗前后炎性因子水平,以及治疗安全性和有效性。结果:治疗组患者外周血炎性因子hs-CRP、IL-6表达水平[(56.90±5.20)、(61.97±5.96)pg/ml]明显高于对照组患者[(36.03±7.28)、(37.73±6.56)pg/ml],差异有统计学意义(t=12.780、14.970,P<0.05)。30例患者采用准分子激光联合药涂球囊方法治疗未出现严重不良事件如死亡、远端栓塞、出血等。术后随访6个月,患者治疗后通畅率达100%。治疗后患者外周血炎性因子hs-CRP、IL-6表达水平[(34.03±4.17)、(32.17±4.89)pg/ml]明显低于术前,差异有统计学意义(P<0.05),与对照组患者相仿,差异无统计学意义(P>0.05)。结论:炎性因子水平与外周动脉支架术后再狭窄呈正相关,准分子激光联合药涂球囊治疗后炎性因子水平下降,对外周动脉支架术后再狭窄具有较好的疗效和安全性。
Objective To investigate the relationship between restenosis and inflammatory factors after peripheral artery stenting and the therapeutic effect of laser combined with the drug-coated balloon.Methods The clinical data of 30 patients with restenosis after peripheral artery stent implantation admitted to the Department of Vascular Surgery,Fuwai Central China Cardiovascular Hospital(Heart Center,Henan Provincial People’s Hospital)and the Department of Vascular Surgery,Henan Provincial People’s Hospital from August 2019 to August 2022 were retrospectively analyzed.At the same time,30 patients without restenosis were selected as the control group.The peripheral blood of the two groups was collected,and the levels of serum inflammatory factors including high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)were detected by enzyme-linked immunosorbent assay(ELISA).Logistic regression equation was used to analyze the correlation between the levels of inflammatory factors in peripheral blood and restenosis after peripheral artery stenting.A total of 30 patients with restenosis after peripheral artery stenting were treated with an excimer laser catheter combined with a drug-coated balloon.The levels of inflammatory factors before and after treatment and the safety and efficacy of the treatment were evaluated.Results The levels of hs-CRP and IL-6 in the treatment group[(56.90±5.20),(61.97±5.96)pg/ml]were higher than those in the observation group[(36.03±7.28),(37.73±6.56)pg/ml],and the difference was statistically significant(P<0.05).There were no serious adverse events such as death,distal embolism,or bleeding in 30 patients treated with the excimer laser catheter combined with the drug-coated balloon.After 6 months of follow-up,the patency rate was 100%.The levels of hs-CRP and IL-6 in the peripheral blood of patients after treatment[(34.03±4.17),(32.17±4.89)pg/ml]were significantly lower than those before treatment,and the difference was statistically significant(P<0.05),which was similar to that o
作者
韩文豪
史帅涛
王国权
Han Wenhao;Shi Shuaitao;Wang Guoquan(Department of Vascular Surgery,Fuwai Central China Cardiovascular Hospital(Heart Center,Henan Provincial People’s Hospital),Zhengzhou 450003,China;Department of Vascular Surgery,Henan Provincial People’s Hospital,Zhengzhou 450003,China)
出处
《中华实验外科杂志》
CAS
北大核心
2023年第6期1164-1166,共3页
Chinese Journal of Experimental Surgery
基金
河南省医学科技攻关计划联合共建项目(LHGJ20200118)。
关键词
外周动脉支架术后再狭窄
炎性因子
准分子激光
药涂球囊
Restenosis after peripheral artery stenting
Inflammatory factors
Excimer laser
Drug-coated balloon
