摘要
2-型糖尿病及其并发症严重危害人类的生命健康,作为我国首个获批上市的C-芳基糖苷类降糖药物,达格列净不仅降糖效果显著,而且在保护心血管、肾脏以及降低体重等方面也有广泛应用。对达格列净的化学结构、催化合成方法、降糖机制及临床应用进行介绍。
Type 2 diabetes mellitus and its complications seriously endanger human life and health.As the first c-aryl glycoside hypoglycemic drug approved for marketing in China,Dapagliflozin not only has significant hypoglycemic effect,but also is widely used in protecting the cardiovascular system,protecting the kidneys and reducing body weight.In this paper,the chemical structure,catalytic synthesis methods,hypoglycemic mechanism and clinical application of Dapagliflozin were introduced.
作者
韩慧磊
吕薇薇
HAN Huilei;LYU Weiwei(College of Chemistry and Materials Engineering,Fuyang Normal University,Fuyang 236037,China)
出处
《宿州学院学报》
2023年第6期41-45,共5页
Journal of Suzhou University
基金
阜阳师范大学博士科研启动经费(2021KYQD0023)。
关键词
降糖药
达格列净
催化合成
临床应用
Hypoglycemic drug
Dapagliflozin
Catalytic synthesis
Clinical application
