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达格列净 被引量:6

Dapagliflozin
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摘要 2014年1月8日美国FDA批准由百时美施贵宝公司(BristolMyersSquibb)开发的降糖药达格列净(dapagliflozin,商品名为Farxiga)在美国上市。达格列净是首个获得批准的钠-葡萄糖协同转运蛋白2(sodium—glucoselinkedtransporter2,SGLT2)抑制剂,用于治疗2型糖尿病。该药物已于2012年11月12日获欧盟委员会批准。
作者 秘芳 董金华
机构地区 沈阳药科大学
出处 《中国药物化学杂志》 CAS CSCD 2014年第4期332-333,共2页 Chinese Journal of Medicinal Chemistry
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参考文献5

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二级参考文献17

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  • 4KASICHA Y ANULA S, CHANG M, HASEGAWA M, et al. Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium-glucose co-transporter type 2, inJapanese subjects without and with type 2 diabetes mellitus[J] . Diabetes Obes Metab, 2011, 13 (4) : 357 - 365. 被引量:1
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  • 9KAKU K, INOUE S, MATSUOKA 0, et al, Efficacy and safety of dapagliflozin as a monotherapy for type 2 diabetes mellitus inJapanese patients with inadequate glyeaernic control: a phase II multicentre, randomized, double-blind, placebo-controlled trial[J]. Diabetes (lbes Metab, 2013,15(5): 432 -440. 被引量:1
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共引文献18

同被引文献28

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  • 2Meng W, Ellsworth BA, Nirschl AA, et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes [J]. JMed Chem, 2008, 51 (5): 1145-1149. 被引量:1
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  • 8秦延涛.一种达格列净异构体杂质的合成方法:中国,105061373A[P].2015-11-18. 被引量:1
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