摘要
目的探讨布地奈德、沙丁胺醇联合乙酰半胱氨酸雾化辅助治疗小儿支气管肺炎的临床疗效。方法选取怀远荆塗医院于2021年7月至2022年6月收治的支气管肺炎患儿72例为研究对象,进行回顾性研究,根据治疗方法不同将患儿分为BS组与BSY组,在常规治疗的基础上,BS组采用布地奈德+沙丁胺醇雾化治疗,BSY组采用布地奈德+沙丁胺醇+乙酰半胱氨酸雾化治疗。比较两组患儿治疗2个疗程后的临床疗效、症状体征改善时间、用药不良反应,以及治疗前后C反应蛋白、血清降钙素原水平的变化情况,以探讨最佳用药方案。结果 BSY组患儿临床总有效率为91.67%(33/36),明显高于BS组患儿72.22%(26/36)(χ^(2)=4.59,P=0.032);BSY组患儿用药期间不良反应发生率为11.11%(4/36),较低于BS组19.44%(7/36),但差异无统计学意义(χ^(2)=0.96,P=0.326);治疗后BSY组患儿血CRP、PCT水平分别为(5.86±5.66)mg/L、(2.59±0.74)μg/L,均低于BS组患儿(15.64±5.85)mg/L、(4.71±0.93)μg/L,差异均有统计学意义(t=7.20、10.70,均P < 0.001)。且BSY组患儿退热、咳嗽、肺部啰音及X线肺部阴影等症状体征消失时间均明显地短于BS组患儿,差异均有统计学意义(t=11.85、4.19、2.72、2.39,均P < 0.05)。结论采用布地奈德、沙丁胺醇、乙酰半胱氨酸三药联合雾化辅助治疗小儿支气管肺炎,能快速缓解患儿的临床症状,改善肺部体征,降低炎症程度,对患儿的治疗效果显著。
Objective To investigate the efficacy of atomization with budesonide,salbutamol,and acetylcysteine in the adjuvant treatment of bronchopneumonia in children.Methods Seventy-two children with bronchopneumonia admitted to Huaiyuan Jingtu Hospital from July 2021 to June 2022 were retrospectively included in this study.These children were divided into BS and BSY groups according to different treatment methods.Based on conventional treatment,the BS group was given atomization treatment with budesonide and salbutamol,and the BSY group was given atomization treatment with budesonide,salbutamol,and acetylcysteine.After two courses of treatment,clinical efficacy,duration to improvements in symptoms and signs,adverse drug reactions,and changes in serum C-reactive protein and procalcitonin levels after treatment relative to those before treatment were compared between the two groups.The optimal medication plan was investigated.Results The total response rate in the BSY group was 91.67%(33 cases/36 cases),which was significantly higher than 72.22%(26/36)in the BS group(χ^(2)=4.59,P=0.032).The incidence of adverse drug reactions in the BSY group was 11.11%(4/36),which was significantly lower than 19.44%(7/36)in the BS group(χ^(2)=0.96,P=0.326).After treatment,the levels of C-reactive protein and procalcitonin in the BSY group were(5.86±5.66)mg/L and(2.59±0.74)μg/L,respectively,which were lower than(15.64±5.85)mg/L and(4.71±0.93)μg/L in the BS group(t=7.20,10.70,both P<0.001).The durations to the disappearance of symptoms and signs including fever,cough,lung rales,and X-ray lung shadow in the BSY group were significantly shorter compared with the BS group(t=11.85,4.19,2.72,2.39,all P<0.05).Conclusion Atomization with budesonide,salbutamol,and acetylcysteine in combination for the adjuvant treatment of bronchopneumonia in children can quickly relieve the clinical symptoms of children,improve the lung signs,reduce the degree of inflammation,and has a remarkable therapeutic effect on bronchopneumonia in children.
作者
翁旭
刘安利
刘玉琼
孙乐乐
陈信
Weng Xu;Liu Anli;Liu Yuqiong;Sun Lele;Chen Xin(Department of Pediatrics,Huaiyuan Jingtu Hospital,Bengbu 233401,Anhui Province,China;Department of Pediatrics,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,Anhui Province,China)
出处
《中国基层医药》
CAS
2023年第7期1040-1044,共5页
Chinese Journal of Primary Medicine and Pharmacy
基金
安徽省教育厅自然科学研究重点项目(KJ2019A0378)。
