摘要
目的探讨2型糖尿病患者血清25-羟维生素D、甲状旁腺激素水平与高血压的相关性。方法选取厦门大学附属第一医院思明院区2018年2月至2020年8月收治的2型糖尿病患者100例为研究对象,根据患者高血压、血清25-羟维生素D水平进行分组,分析不同水平血清25-羟维生素D、甲状旁腺激素与高血压的相关性。结果 100例2型糖尿病患者中,高血压1级25例、2级30例、3级45例,血清25-羟维生素D水平充足5例(5%)、不足10例(10%),缺乏85例(85%)。1级、2级、3级高血压患者的血清25-羟维生素D分别为(12.18±2.52)μg/L、(12.45±2.39)μg/L、(10.33±1.26)μg/L,甲状旁腺激素分别为(36.48±0.25)ng/L、(41.15±0.39)ng/L、(47.52±1.44)ng/L,随着血压的升高,患者血清25-羟维生素D水平呈先增后降趋势,而甲状旁腺激素水平则呈逐渐增加趋势,但不同高血压分级与患者血清25-羟维生素D、甲状旁腺激素水平差异均无统计学意义(F=0.96、1.93,均P > 0.05)。logistic回归分析显示,2型糖尿病患者伴发高血压与患者的年龄、身体质量指数、血清25-羟维生素D水平、糖化血红蛋白、甲状旁腺激素水平均有相关性(OR=1.076、1.266、0.937、1.257、1.000,均P < 0.05)。结论 2型糖尿病患者血清25-羟维生素D、甲状旁腺激素水平与患者高血压有关。
Objective To correlate serum 25-hydroxylvitamin D and parathyroid hormone levels with hypertension in patients with type 2 diabetes mellitus.Methods A total of 100 patients with type 2 diabetes mellitus admitted to Siming Branch,the First Affiliated Hospital of Xiamen University,China from February 2018 to August 2020 were included in this study.These patients were stratified according to hypertension,and serum 25-hydroxyvitamin D level.The correlation between serum 25-hydroxyvitamin D and parathyroid hormone and hypertension was analyzed.Results Among the 100 patients with type 2 diabetes meliitus,25 patients had grade 1 hypertension,30 patients had grade 2 hypertension,45 patients had grade 3 hypertension,5 patients(5%)had sufficient levels of 25-hydroxyvitamin D,10 patients(10%)had insufficient levels of 25-hydroxyvitamin D,85 patients(85%)had inadequate levels of 25-hydroxyvitamin D.Serum levels of 25-hydroxyvitamin D in patients with grade 1,grade 2,and grade 3 hypertension were(12.18±2.52)μg/L,(12.45±2.39)μg/L,(10.33±1.26)μg/L,respectively,and parathyroid hormone levels were(36.48±0.25)ng/L,(41.15±0.39)ng/L,and(47.52±1.44)ng/L,respectively.As blood pressure increased,the patient's serum levels of 25-hydroxyvitamin D increased first and then decreased,while parathyroid hormone levels gradually increased.However,there were no statistically significant differences in serum levels of 25-hydroxyvitamin D and parathyroid hormone between patients of different hypertension grades(F=0.96,1.93,both P>0.05).Logistic regression analysis showed that hypertension in type 2 diabetes patients was correlated with age,body mass index,serum 25 hydroxyvitamin D level,glycated hemoglobin and parathyroid hormone level(OR=1.076,1.266,0.937,1.257,1.000,all P<0.05).Conclusion The serum levels of 25-hydroxyvitamin D and parathyroid hormone in patients with type 2 diabetes mellitus are related to hypertension.
作者
钟斌理
张岩
Zhong Binli;Zhang Yan(Department of Internal Medicine,Siming Branch,the First Affiliated Hospital of Xiamen University,Xiamen 361000,Fujian Province,China;Department of Endocrinology,Zhongshan Hospital,Xiamen University,Xiamen 361004,Fujian Province,China)
出处
《中国基层医药》
CAS
2023年第7期987-990,共4页
Chinese Journal of Primary Medicine and Pharmacy
