摘要
目的分析年龄因素对新型冠状病毒奥密克戎变异株感染轻症患者临床症状及核酸转阴时间的影响。方法收集笔者参与支援吉林省抗击新型冠状病毒感染期间所工作的长春市奢岭方舱医院收治的348例新型冠状病毒奥密克戎变异株感染轻症患者临床资料,将患者按年龄分为儿童组(5~<12岁)7例,少年组(12~<18岁)19例,青年组(18~<35岁)116例,中青年组(35~<45岁)67例,中年组(45~<60岁)106例,老年组(≥60岁)33例,分析不同年龄段患者临床症状特点及其连续两次核酸转阴时间。结果新型冠状病毒奥密克戎变异株感染轻型患者主要临床症状占比较高的前3位依次是咳嗽、咽痛和发热,且症状个数以无症状和1个症状为主。各组主要临床症状和症状个数比较差异无统计学意义(P>0.05);青年组、中青年组、中年组、老年组中有基础疾病和无基础疾病患者核酸转阴时间比较,差异无统计学意义(P=1.000、0.667、0.551、0.800)。结论年龄对新型冠状病毒奥密克戎变异株感染轻症患者的临床症状和核酸转阴时间无显著影响,该研究发现可为新型冠状病毒奥密克戎变异株感染轻症患者救治提供新策略。
Objective To analyze the effect of age factors on the clinical symptoms and nucleic acid to negative time in mild patients with Omicron variant of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)infection.Methods The clinical data of 348 cases of mild patients with Omicron variant of SARS-CoV-2 infection were collected from Sheling cabin Hospital of Changchun,where the author worked during the period of supporting the fight against Corona Virus Disease 2019 in Jilin Province.The patients were divided by age into children group(5-<12 years old)7 cases,juvenile group(12-<18 years old)19 cases,young group(18-<35 years old)116 cases,young and middle-aged group(35-<45 years old)67 cases,middle-aged group(45-<60 years old)106 cases,elderly group(≥60 years old)33 cases.The clinical symptoms of patients in different age groups and the time of their two consecutive nucleic acids turned negatives were analyzed.Results The top three mainly clinical symptoms of mild patients infected with Omicron variant of SARS-CoV-2 accounted for a relatively high proportion were cough,sore throat and fever,and the number of symptoms were mainly asymptomatic and single symptoms.There was no significant difference in main clinical symptoms and the number of symptoms among all groups(P>0.05).There was no significant difference in nucleic acid-negative conversion time between the young group,young and middle-aged group,elderly group with and without underlying diseases(P=1.000,0.667,0.551,0.800).Conclusion Age has no significant effect on the clinical symptoms and the time of negative nucleic acid transition in mild patients with Omicron variant of SARS-CoV-2 infection.The study finds that it can provide a new strategy for the treatment of mild patients with Omicron variant of SARS-CoV-2 infection.
作者
罗利萍
刘斌
李正汉
肖骏
钮柏琳
LUO Liping;LIU Bin;LI Zhenghan;XIAO Jun;NIU Bailin(Department of Intensive Care Medicine,Chongqing University Central Hospital/Chongqing Emergency Medical Center/Chongqing Fourth People′s Hospital,Chongqing 400010,China;Department of Cardiovascular Medicine,Chongqing University Central Hospital/Chongqing Emergency Medical Center/Chongqing Fourth People′s Hospital,Chongqing 400010,China;Department of Intensive Care Medicine,the First Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《国际检验医学杂志》
CAS
2023年第15期1895-1901,共7页
International Journal of Laboratory Medicine
基金
重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0124)
重庆医科大学新冠肺炎临床研究专项项目(X1-2611)。
关键词
新型冠状病毒
奥密克戎变异株
年龄
临床症状
核酸转阴时间
Severe Acute Respiratory Syndrome Coronavirus 2
Omicron variant
age
clinical symptoms
nucleic acid-negative conversion time
